文献类型：期刊文献

英文题名：Palladium-Catalyzed Divergent Regioselective Homocoupling and Hydroxylation of 3-Arylbenzo[d]isoxazoles

作者：Guo, Ying[1];Yu, Kun-Kun[1];Xing, Li-Hao[1];Liu, Hong-Wei[1];Wang, Wei[2];Ji, Ya-Fei[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]Univ New Mexico, Dept Chem & Chem Biol, MSC03 2060, Albuquerque, NM 87131 USA

年份：2017

卷号：359

期号：3

起止页码：410

外文期刊名：ADVANCED SYNTHESIS & CATALYSIS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000394586400007)】；

基金：We gratefully thank the National Natural Science Foundation of China (Project Nos. 21476074, 21572055 and 21676088) and Research Fund for the Doctoral Program of Higher Education of China (Project No. 20130074110009) for financial support.

语种：英文

外文关键词：benzoisoxazoles; C-H bond activation; divergent synthesis; homocoupling; hydroxylation

摘要：Palladium-catalyzed oxidative homocoupling and hydroxylation of 3-arylbenzo[d]isoxazoles have been developed via direct C(sp(2))-H bond activation using benzoisoxazoles as a new directing group. The protocols offer a divergent approach to functionalized, synthetically useful benzoisoxazoles in good yields. Critically, 1-iodo-4-methoxybenzene functions as an oxidant to mediate the dehydrogenative homocoupling and minimize the cross-coupling. A dual-core dimeric palladacycle intermediate is confirmed by X-ray crystallography, and serves as an active catalytic species in the catalytic cycles.