文献类型：期刊文献

英文题名：An ultra-low noise amplifier array system for high throughput single entity analysis

作者：Zhong, Cheng-Bing[1]; Ma, Hui[1]; Wang, Jia-Jun[1]; Zhang, Lin-Lin[1]; Ying, Yi-Lun[1,2]; Wang, Rong[3]; Wan, Yong-Jing[3]; Long, Yi-Tao[1]

机构：[1] State Key Laboratory of Analytical Chemistry for Life Science, Nanjing University, School of Chemistry and Chemical Engineering, Nanjing, 210023, China; [2] Chemistry and Biomedicine Innovation Center, Nanjing University, Nanjing, 210023, China; [3] School of Information Science and Engineering, East China University of Science and Technology, Shanghai, 200237, China

年份：2021

卷号：233

起止页码：33

外文期刊名：Faraday Discussions

收录：EI(收录号：20221912073303)

语种：英文

外文关键词：Bandwidth - Low noise amplifiers

摘要：Electrochemical measurements at the single entity level provide ultra-sensitive tools for the precise diagnosis and understanding of basic biological and chemical processes. By decoding current signatures, single-entity electrochemistry provides abundant information on charges, sizes, shapes, catalytic performances and compositions. The accuracy of single-entity electrochemistry highly relies on advanced instrumentation to achieve the amperometric resolution at the sub-picoampere level and the temporal resolution at the sub-microsecond level. Currently, it is still a challenge for paralleling amplifiers to allow low-noise and high bandwidth single-entity electrochemical measurements. Herein, we developed a low-noise four-channel electrochemical instrumentation that integrates an Au electrode array with amplifiers in the circuit board. With this amplifier array, we achieved a high bandwidth (>100 kHz) electrochemical measurement. The further practical experiments proved the capability of this amplifier array system in acquiring transient signals from both single-molecule detection with an aerolysin nanopore and single Pt nanoparticle catalysis during the dynamic collision process. Paired with appropriate microfluidic array systems, our instrumentation will enable an extraordinarily high-throughput feature for single-entity sensing. ? 2022 The Royal Society of Chemistry