文献类型：期刊文献

中文题名：Synthesis of Diverse Oxetane Amino Acids via Visible-Light-Induced Photocatalytic Decarboxylative Giese-Type Reaction

作者：Haoliang Shi[1];Yi Wan[1];Yongqiang Zhang[1]

机构：[1]Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism,Shanghai Key Laboratory of New Drug Design,and School of Pharmacy,East China University of Science and Technology,Shanghai,200237 China

年份：2024

卷号：42

期号：12

起止页码：1341

中文期刊名：Chinese Journal of Chemistry

外文期刊名：中国化学（英文版）

收录：CSTPCD;;Scopus;CSCD:【CSCD2023_2024】；PubMed;

基金：Financial support from the program of the National Natural Science Foundation of China(21871086 and 22171080,Y-Q.Z.);Natural Science Foundation of Shanghai(23ZR1417200,Y.-Q.Z.)isgratefullyacknowledged.

语种：英文

中文关键词：Photoredox catalysis;Decarboxylative Giese-type reaction;Oxetane amino acids;Amino acids;Synthesis;Radical reactions

摘要：The divergent synthesis of versatile 3,3′-disubstituted oxetane amino acids by utilizing visible-light-induced photocatalytic decarboxylative Giese-type reaction has been demonstrated.3-Methyleneoxetane-derived substrates are readily available in a single-step and highly reactive as radical acceptors,allowing the production of versatile oxetaneγ-andα-amino acids in high yields.A distinct ring strain release-driven radical addition mechanism was preliminarily revealed.The preparative power was further highlighted by the application in the synthesis of oxetane-containing dipeptides and azetidine amino acids,as well as the transformation of the product into novel oxetane-containing spiro-heterocycle pharmacophore.