文献类型：期刊文献

英文题名：Base-base bifunctional catalysis:: A practical strategy for asymmetric Michael addition of malonates to α,β-unsaturated aldehydes

作者：Wang, Yongcan[1];Li, Pengfei[1];Liang, Xinmiao[1,2];Ye, Jinxing[1,2]

机构：[1]Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China;[2]E China Univ Sci & Technol, Sch Pharm, Minist Educ, Engn Res Ctr Pharmaceut Proc Chem, Shanghai 200237, Peoples R China

年份：2008

卷号：350

期号：9

起止页码：1383

外文期刊名：ADVANCED SYNTHESIS & CATALYSIS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000256976100031)，CCR-EXPANDED(收录号:WOS:000256976100031)】；

语种：英文

外文关键词：aldehydes; asymmetric catalysis; bifunctional catalysis; malonates; Michael addition

摘要：Lewis base-Bronsted base bifunctional catalysis is a novel and practical strategy for the asymmetric Michael addition. The addition of malonates to a series of cc,p-unsaturated aldehydes can take place under base-base bifunctional catalytic conditions using 0.5-5 mol% of (S)-2-[diphenyl(trimethyl-silyloxy)methyl]pyrrolidine as catalyst and 5-30 mol% of lithium 4-fluorobenzoate as additive base with up to 99% ee.