文献类型：期刊文献

英文题名：Palladium-catalyzed multi-acetoxylation of 1,3-disubstituted 1H-pyrazole-5-carboxylates via direct C(sp2)-H or C(sp3)-H bond activation

作者：Ding, Jun[1];Guo, Ying[1];Shao, Ling-Yan[1];Zhao, Fei-Yi[1];Liao, Dao-Hua[1];Liu, Hong-Wei[1];Ji, Ya-Fei[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China

年份：2016

卷号：27

期号：10

起止页码：1617

外文期刊名：CHINESE CHEMICAL LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000387629400009)】；

基金：The authors are grateful to the National Natural Science Foundation of China (Nos. 21176074 and 21476074) and the Research Fund for the Doctoral Program of Higher Education of China (No. 20130074110009) for financial support.

语种：英文

外文关键词：Palladium catalysis; Functionalized pyrazoles; Multi-acetoxylation; C-H activation; Monodentate directing group

摘要：A palladium-catalyzed multi-acetoxylation of 1,3-disubstituted 1H-pyrazole-5-carboxylate derivatives containing multiple potential reactive sites is described. Therein, the sequence of this process has been appropriately investigated. The protocol mainly provides the di- and tri-acetoxylated products for 1,3-diarylpyrazoles. Besides, it is found that the acetoxylation of C(sp(3))-H bond is prior to that of C(sp(2))-H bond under structurally competitive conditions. (C) 2016 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.