文献类型：期刊文献

英文题名：Designing Tetrahydroimidazo[1,2-a]pyridine Derivatives via Catalyst-free Aza-Diels-Alder Reaction (ADAR) and Their Insecticidal Evaluation

作者：Zhang, Wenwen[1];Chen, Yinbo[1];Chen, Weidong[1];Liu, Zewen[2];Li, Zhong[1]

机构：[1]E China Univ Sci & Technol, Shanghai Key Lab Chem Biol, Inst Pesticides & Pharmaceut, Shanghai 200237, Peoples R China;[2]Nanjing Agr Univ, Key Lab Monitoring & Management Plant Dis & Insec, Minist Agr, Nanjing 210095, Peoples R China

年份：2010

卷号：58

期号：10

起止页码：6296

外文期刊名：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000277721900053)】；

基金：Received for review February 16, 2010. Revised manuscript received April 15, 2010. Accepted April 19, 2010. This work was financially supported by the National Basic Research Program of China (973 Program, 2010CB126100 and 2010CBI26200), the National High Technology Research and Development Program of China (2006AA-10A201 and 2008AA10Z413), a National Science Foundation China Program Grant (20872034), and New Century Excellent Talents in University (NCET070284). This work was also partly supported by the Shanghai Foundation of Science and Technology (09XD1401300, 073919107), the Shanghai Leading Academic Discipline Project (13507), and the 111 Project (1107023).

语种：英文

外文关键词：Aza-Diels-Alder; catalyst-free; insecticide; biological activities

摘要：A series of tetrahydroimidazo[1,2-a]pyridine derivatives were synthesized by the reaction of 2-vinyl-4,5-dihydroimidazole derivatives with substituted benzylidenemalononitrile via a catalyst-free aza-Diels-Alder reaction. Insecticidal activities of target compounds were tested against pea aphids (Aphis craccivora), which showed that activities were strongly influenced by the substituents and their positions. Especially, the introduction of a fluoro group at the 2- position increased activities.