文献类型：期刊文献

英文题名：Multi-dimensional donor engineering of NIR-II AIEgens for multimodal phototheranostics of orthotopic breast cancer

作者：Yuan, Tao[1];Cui, Jie[2,3];Zhu, Jun[2];Mei, Ju[1];Wang, Dong[2];Hua, Jianli[1]

机构：[1]East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Frontiers Sci Ctr Materiobiol & Dynam Chem, Sch Chem & Mol Engn,Key Lab Adv Mat & Joint Int Re, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]Shenzhen Univ, Coll Mat Sci & Engn, Ctr AIE Res, Guangdong Prov Key Lab New Energy Mat Serv Safety, Shenzhen 518060, Peoples R China;[3]Guangdong Med Univ, Sch Pharm, Dongguan 523808, Peoples R China

年份：2025

卷号：319

外文期刊名：BIOMATERIALS

收录：;EI(收录号：20250817924534);WOS:【SCI-EXPANDED(收录号:WOS:001435337000001)】；

基金：For financial support of this research, the authors thank the projects supported by the National Natural Science Foundation of China (21788102, 22271093 and 21971064) , Shanghai Municipal Science and Technology Major Project (Grant No.2018SHZDZX03) , the Fundamental Research Funds for the Central Universities (222201717003 and 50321101918001) and the Programme of Introducing Talents of Discipline to Universities (B16017) . The authors thank Research Center of Analysis and Test of East China University of Science and Technology for the help on the characterization.

语种：英文

外文关键词：Multimodal phototheranostics; Donor engineering; Second near-infrared region; Aggregation-induced emission; Orthotopic cancer elimination

摘要："One-for-all" multimodal phototheranostic agents, which integrate multiple photodiagnostic and phototherapeutic functionalities into a single component, have emerged as promising platforms for advancing cancer treatment. Among these, agents featuring second near-infrared (NIR-II) emission are particularly appealing due to their superior tissue penetration depth and high signal-to-background ratio (SBR). However, most reported NIR-II fluorophores suffer from severely imbalanced radiative and non-radiative excited-state energy dissipation in biological environments, resulting in extremely low fluorescence quantum yields (QYs) and limited diagnostic efficacy. This highlights the urgent need for innovative molecular design strategies to develop high-performance NIR-II "one-for-all" multimodal phototheranostic agents. Herein, we present, for the first time, a multidimensional donor engineering protocol that optimizes donor design at the molecular, aggregated, and solvent-interaction levels. By introducing 2,4,4-trimethylpentan-2-yl groups into the diphenylamine indeno[1,2b]thiophene donor unit, we developed a donor-acceptor-donor (D-A-D) type NIR-II aggregation-induced emission-active luminogen (AIEgen), i.e. OPITBT. When formulated into nanoparticles (NPs), OPITBT NPs exhibited a 16-fold enhancement in fluorescence QY compared to OPITBT in tetrahydrofuran, along with excellent photothermal conversion efficiency (PCE) and acceptable type-I reactive oxygen species (ROS) generation. When further fabricated into tumor-targeting NPs, the resulted OPITBT-R NPs effectively eliminated orthotopic breast cancer through fluorescence-photoacoustic-photothermal multimodal imaging-guided photodynamic-photothermal synergistic therapy under single 808 nm laser irradiation. Notably, the exceptional NIR-II fluorescence brightness of OPITBT-R NPs enables high-resolution NIR-IIb whole-body vascular imaging in living mice. This work provides a versatile strategy to enhance radiative dissipation of NIR-II fluorophores for balanced phototheranostic performance and advances the development of "one-for-all" phototheranostic systems.