文献类型：期刊文献

中文题名：氧化硅纳米颗粒的形貌和孔结构的调控及其对药物输运性能影响

英文题名：Drug Delivery Performances of Silica Nanoparticles with Tunable Morphologies and Pore Structures

作者：江钰[1];牛德超[1];李永生[1]

机构：[1]华东理工大学材料科学与工程学院低维材料化学研究室,上海200237

年份：2019

卷号：45

期号：2

起止页码：250

中文期刊名：华东理工大学学报（自然科学版）

外文期刊名：Journal of East China University of Science and Technology

收录：CSTPCD;;Scopus;北大核心:【北大核心2017】；CSCD:【CSCD_E2019_2020】；

基金：国家自然科学基金(51572083);上海市科技启明星计划(16QA1401300)

语种：中文

中文关键词：多级孔;氧化硅;形貌调控;药物输运

外文关键词：hierarchical pores;silica;morphological control;drug delivery

摘要：以阳离子表面活性剂十六烷基三甲基溴化铵(CTAB)和两亲性嵌段共聚物聚苯乙烯-b-聚丙烯酸(PS-b-PAA)为双模板剂,以正硅酸乙酯(TEOS)为硅源,通过精确调控模板剂与硅源之间的界面自组装行为,制备了3种多级孔氧化硅纳米颗粒,包括核壳型双介孔氧化硅纳米颗粒(CS-DMSNs)、嵌入型双介孔氧化硅纳米颗粒(E-DMSNs)及空心型介孔氧化硅纳米颗粒(H-MSNs)。利用透射和扫描电镜、氮气吸附-脱附等表征方法对多级孔氧化硅纳米颗粒形貌和孔结构进行分析,探讨其作为药物输运载体时的形貌和孔结构对载药量、释放性能及细胞存活率的影响规律。
Mesoporous silica nanoparticles have been widely used in biomedicine due to their high surface area,large pore volume and good biocompatibility.However,the precise control of the silica-based particles morphology and pore structure is still a great challenge.In this study,by employing cationic surfactant cetyl trimethyl ammonium bromide (CTAB) and amphiphilic block copolymer polystyrene-b-poly (acrylic acid)(PS-b-PAA) as the organic templates,tetraethoxysilane (TEOS) as the silicon source,three kinds of hierarchical porous silica nanoparticles with different morphologies,including core-shell structured dual-mesoporous silica nanospheres (CS-DMSNs),embedded dual-mesoporous silica nanospheres (E-DMSNs) and hollow mesoporous silica nanospheres (H-MSNs),were prepared by precisely controlling the interfacial self-assembly behaviors between the organic templates and the silicon source.The morphologies and pore structures of these samples were characterized by transmission electron microscopy (TEM),field-emission scanning electron microscopy (FE-SEM),N2 absorption-desorption and so on.Results show that both CS-DMSNs and H-MSNs have silica shells distributed with small pores of 1.5 nm,while E-DMSNs have interconnected large mesopores of 11.7 nm and small pores of 1.5 nm in the silica framework.Moreover,the drug loading and delivery performance of these three kinds of hierarchical porous silica nanoparticles was investigated systematically.Especially,as a drug delivery carrier,the effects of particle morphology/pore structure on the loading amounts,release behaviors and in vitro cell viabilities were evaluated.Results indicate that all these three hierarchical porous silica nanoparticles have high drug loading amount and pH-responsive drug releasing behavior.Specifically,compared to the CS-DMSNs and H-MSNs,E-DMSNs display the optimal drug delivery capability in drug loading and cytotoxicity due to their exposed large-mesopore structure and embedded small pores in the silica framework.This study will provide new ideas and methods for the construction of a new type of porous silica nanoparticles for efficient and safe treatment of tumors.