文献类型：期刊文献

英文题名：Biomaterial-assisted therapeutic cell production and modi fi cation in vivo

作者：Dai, Kai[1,2,3];Wang, Jing[1,2,3,4];Liu, Changsheng[1,3,4]

机构：[1]East China Univ Sci & Technol, Engn Res Ctr Biomed Mat, Minist Educ, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai, Peoples R China;[3]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Shanghai, Peoples R China;[4]East China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Shanghai, Peoples R China

年份：2024

卷号：133

外文期刊名：EXPERIMENTAL HEMATOLOGY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001222350000001)】；

基金：This research was supported by the Basic Science Center Program (No. T2288102) , the Key Program of the National Natural Science Foundation of China (No. 32230059) , the National Natural Science Foundation of China (No. 32301123) , the Foundation of Frontiers Science Center for Materiobiology and Dynamic Chemistry (No. JKVD1211002) , the Wego Project of Chinese Academy of Sciences (No. [2020]005) , and the China Postdoctoral Science Foundation (No. 2022M721147) .

语种：英文

摘要：Hematopoietic stem cell transplantation remains the preferred treatment for a variety of hematopoietic function disorders. To address the issue of limited numbers of hematopoietic stem/progenitor cells (HSPCs), significant progress has been made in the technology for ex vivo expansion of HSPCs. In addition, biomaterial-assisted in vivo production technology for therapeutic cells, including HSPCs, is gradually gaining attention. With the aid of specifically functional biomaterials, researchers can construct bone -like tissues exhibiting typical bone marrow -like structures (termed in vivo osteo-organoids in this article) for the production of therapeutic cells. These in vivo osteoorganoids mimic the native bone marrow niche and provide a microenvironment conducive to the expansion and differentiation of HSPCs. In this perspective article, we systematically summarize the history of in vivo osteo-organoids as a model for studying hematopoiesis and cancer metastasis and propose the challenges faced by the in vivo osteo-organoid production platform for therapeutic cells in terms of clinical translation. Ultimately, we hope to achieve functional customization of in vivo osteo-organoid-derived cells through continuously developed material design methods, so as to meet the treatment needs of different types of diseases and bring hope for life to more people. (c) 2024 ISEH - Society for Hematology and Stem Cells. Published by Elsevier Inc. All rights reserved.