文献类型：期刊文献

英文题名：Formation of graphene oxide-hybridized nanogels for combinative anticancer therapy

作者：Xu, Xin[1];Wang, Jine[1];Wang, Yifeng[1];Zhao, Liming[1];Li, Yulin[1,2,3];Liu, Changsheng[1]

机构：[1]East China Univ Sci & Technol, Minist Educ, Engn Res Ctr Biomed Mat, State Key Lab Bioreactor Engn,Key Lab Ultrafine M, Shanghai 200237, Peoples R China;[2]Donghua Univ, Minist Educ, Key Lab Text Sci & Technol, Shanghai, Peoples R China;[3]East China Univ Sci & Technol, Shanghai Collaborat Innovat Ctr Biomfg, Shanghai, Peoples R China

年份：2018

卷号：14

期号：7

起止页码：2387

外文期刊名：NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE

收录：;EI(收录号：20172603810481);WOS:【SCI-EXPANDED(收录号:WOS:000446496900038)】；

基金：This research was supported by Shanghai International Cooperation Program (15520721200) and Shanghai Municipal Natural Science Foundation (15ZR1408500). We also acknowledged the financial support from Fundamental Research Funds for the Central Universities (WD1714002, WD1717015).

语种：英文

外文关键词：Graphene oxide; Photothermal therapy; pH/redox-sensitivity; Nanogels; Anticancer drug delivery

摘要：The low efficacy and high toxicity of chemotherapy have been driving increasing attention on development of combined anticancer therapy technique. In the current work, graphene oxide (GO)-hybridized nanogels (AGD) were developed for delivery of an anticancer drug (doxorubicin (DOX)), which simultaneously presented photothermal therapeutic effects against cancer cells. AGD nanogels were fabricated by in situ incorporating GO nanoplatelets into a biodegradable polymer (alginate) via a double emulsion approach using a disulfide molecule as crosslinker, followed by DOX encapsulation via electrostatic interactions. The nanogels released DOX drug in an accelerated way under both acidic and reducible conditions mimicking extracellular tumor microenvironments and intracellular compartments. The stimulative release controllability of the nanogels improved the DOX internalization and long-term drug accumulation inside A549 cells (an adenocarcinoma human alveolar basal epithelial cell line), which, together with their photothermal effect, resulted in a good anticancer cytotoxicity, indicating their promising potential for combinative anticancer therapy. (c) 2017 Elsevier Inc. All rights reserved.