文献类型：期刊文献

英文题名：Copper-Catalyzed One-Pot Oxidation-Aldol/Henry Reaction of Benzylic Amines to α,β-Unsaturated Methyl Ketone/Nitro Compounds

作者：Liu, Jia[1,2];Zhu, Xiao-Rui[1];Ren, Jiangmeng[1,2];Chen, Wei-Dong[2];Zeng, Bu-Bing[1,2,3]

机构：[1]E China Univ Sci & Technol, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China;[3]Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China

年份：2013

卷号：24

期号：20

起止页码：2740

外文期刊名：SYNLETT

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000328335500022)，CCR-EXPANDED(收录号:WOS:000328335500022)】；

基金：We are grateful for financial support from The Fundamental Research Funds for the Central Universities (WY1113007).

语种：英文

外文关键词：aldol reaction; amines; copper; condensation; oxidation

摘要：A novel one-pot synthesis of ,-unsaturated methyl ketone/nitro compounds from benzylic amines through an oxidation-aldol/Henry reaction is reported. The reaction proceeded well by using MCPBA as oxidant and CuCl(2)2H2O as catalyst. A variety of functionalized ,-unsaturated methyl ketone/nitro compounds were assembled in moderate yields by application of this catalytic one-pot reaction.