文献类型：期刊文献

英文题名：Fluorogenic Resveratrol-Confined Graphene Oxide For Economic and Rapid Detection Of Alzheimer's Disease

作者：He, Xiao-Peng[1,2];Deng, Qiong[1,2];Cai, Liang[1,2];Wang, Chang-Zheng[1,2,3];Zang, Yi[3];Li, Jia[3];Chen, Guo-Rong[1,2];Tian, He[1,2]

机构：[1]E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China;[3]Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, State Key Lab Drug Res, Shanghai 201203, Peoples R China

年份：2014

卷号：6

期号：8

起止页码：5379

外文期刊名：ACS APPLIED MATERIALS & INTERFACES

收录：;EI(收录号：20141917690153);WOS:【SCI-EXPANDED(收录号:WOS:000335086000008)】；

基金：We thank the 973 project (2013CB733700), the National Science Fund for Distinguished Young Scholars (81125023), the National Natural Science Foundation of China (21176076, 21202045 and 81173033), and the Key Project of Shanghai Science and Technology Commission (13NM1400900).

语种：英文

外文关键词：graphene; Alzheimer's disease; resveratrol; amyloid beta; fluorogenic; detection

摘要：Developing an effective means for the real-time probing of amyloid beta (A beta) that is closely implicated in Alzheimer's disease (AD) could help better understand and monitor the disease. Here we describe an economic approach based on the simple composition of a natural product, resveratrol (Res), with graphene oxide (GO) for the rapid, fluorogenic recognition of A beta. The Res@GO composite has proved specific for A beta over a range of proteins and ions, and could sensitively capture both A beta monomers and fibers in a physiological buffer solution within only 3 min. The composite can also fluorescently image amyloid deposits in a mouse brain section within 30 min. This new protocol is much cheaper and more timesaving than the conventional immunofluorescence staining technique employed clinically, providing an economic tool for the concise detection of AD.