文献类型：期刊文献

中文题名：A sequential continuous flow synthesis and purification process of calcium dibutyryladenosine cyclophosphate

作者：Liming Cao[1];Maolin Sun[2];Chaoming Liang[2];Lei Yang[1];Yueyue Ma[2];Ruihua Cheng[2];Yanxiong Ke[1];Wei Yu[1,3];Jinxing Ye[1,2]

机构：[1]Engineering Research Center of Pharmaceutical Process Chemistry,Ministry of Education,School of Pharmacy,East China University of Science and Technology,Shanghai 200237,China;[2]School of Biomedical and Pharmaceutical Sciences,Guangdong University of Technology,Guangzhou 510006,China;[3]Shanghai No.1 Biochemical&Pharmaceutical Co.,Ltd.,Shanghai 200080,China

年份：2024

卷号：35

期号：2

起止页码：402

中文期刊名：Chinese Chemical Letters

外文期刊名：中国化学快报(英文版)

收录：CSTPCD;;Scopus;CSCD:【CSCD2023_2024】；PubMed;

基金：supported by the National Natural Science Foundation of China(No.22278087)。

语种：英文

中文关键词：Flow chemistry;Calcium dibutyryladenosine cyclophosphate;Continuous flow synthesis;In-line purification;3D circular cyclone-type micromixer chip

摘要：Calcium dibutyryladenosine cyclophosphate is a widely used cardiovascular drug.The traditional batch synthesis process suffers from long reaction times,tedious operations,and unstable yields.Herein,a sequential continuous flow synthesis combined with a multistage in-line purification process of calcium dibutyryladenosine cyclophosphate was developed.The acylation reaction was completed in a continuous coil reactor at 160℃in 20 min.And the high toxic solvent pyridine was replaced by acetonitrile.Furthermore,the multistage in-line purification process was integrated into the homemade 3D circular cyclone-type micromixer chip.Combining with the membrane phase separators,the residence time of the purification step was 30 s.The isolated yield of this sequential continuous process was 92%with 99%purity.