文献类型：期刊文献

中文题名：Decellularized extracellular matrix and mesenchymal stem cells promote recovery in traumatic brain injury by synergistically enhancing neurogenesis and attenuating neuroinflammation

作者：Xuewei Zhang[1];Bixue Wang[1];Hua Hong[1];Ying Wang[1];Jiashang Liu[1];Changsheng Liu[1];Xi Chen[1]

机构：[1]Key Laboratory for Ultrafine Materials of Ministry of Education,Frontiers Science Center for Materiobiology and Dynamic Chemistry,Engineering Research Center for Biomaterials of Ministry of Education,School of Materials Science and Engineering,East China University of Science and Technology,Shanghai 200237,China

年份：2023

期号：7

起止页码：17

中文期刊名：Journal of Materials Science & Technology

外文期刊名：材料科学技术（英文版）

收录：CSTPCD;;Scopus;CSCD:【CSCD2023_2024】；PubMed;

基金：This work was financially supported by the National Natural Science Foundation of China(Nos.51621002 and 32101151);the Fundamental Research Funds for the Central Universities(No.JKD01221714).We acknowledge Prof.X.D.Kong(Zhejiang Sci-Tech University)and Prof.Q.H.Li(Wenzhou Institute,University of Chinese Academy of Sciences)for helpful discussion.Any opinions,findings,conclusions,or recommendations expressed herein are those of the author(s).

语种：英文

中文关键词：ECM;Stem cells;Brain injury;Neurogenesis;Neuroinflammation

摘要：Damaged neurons and harsh microenvironments contribute to the injury cascades following traumatic brain injury(TBI).Mesenchymal stem cell(MSC)therapy is considered a viable choice for brain in-jury treatment;however,its clinical use is hindered by limited engraftment,low survival ratio,and uncontrolled differentiation.Herein,the decellularized brain extracellular matrix(dBECM)was prepared through a new method as a delivery system for MSCs.dBECM-based hydrogel with favorable biochem-ical and biomechanical features provides a microenvironment for MSCs in nerve repair.The MSCs-encapsulated dBECM-based hydrogel is shown to improve neuron compensation and structural regen-eration,alleviate neuroinflammation,and promote M1-to-M2 polarization of microglia.Our results first demonstrate that the combination of dBECM and MSCs is a critical vehicle to promote TBI repair from neurogenesis and immunoregulation,showing promise for the physiological recovery of neurogenic dis-eases and injuries.