文献类型：期刊文献

英文题名：Chiral counteranion-directed silver-catalyzed asymmetric synthesis of 1,2-dihydroisoquinolines by Friedel-Crafts alkylation reactions

作者：Zhang, Jun-Wei[1,2];Xu, Zhe[2];Gu, Qing[2];Shi, Xiao-Xin[1];Leng, Xue-Bing[2];You, Shu-Li[1,2]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China;[2]Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

年份：2012

卷号：68

期号：26

起止页码：5263

外文期刊名：TETRAHEDRON

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000305381700023)，CCR-EXPANDED(收录号:WOS:000305381700023)】；

基金：We thank MOST (973 Program 2010CB833300) and NSFC (21121062, 21025209, 21002111) for financial support.

语种：英文

外文关键词：Chiral counteranion; 1,2-Dihydroisoquinoline; Friedel-Crafts alkylation; Chiral sliver phosphate; Asymmetric synthesis

摘要：The reaction of ortho-alkynylaryl aldimines and indoles catalyzed by a silver binol-derived phosphate was realized to afford a series of enantioenriched 1,2-dihydroisoquinolines in moderate to good yields and ee. An interesting phenomenon that highly enantioenriched products could be obtained from their lower ee form by silica gel column chromatography was observed, providing an easy access to the enantiopure form of the product. (C) 2012 Elsevier Ltd. All rights reserved.