文献类型：专利

英文题名：New pyrrole derivative used for preparing medicine for treating androgen receptor activity-related disorder, particularly prostate cancer, prostatic hyperplasia, hirsutism, acne, baldness, breast cancer, and/or sexual excitement

作者：HUANG J;XU X;LI Z;LIU P;QIAN X;SHEN H;XIA S;DENG X

机构：[1]UNIV EAST CHINA SCI & TECHNOLOGY

申请号：CN103450112-A

申请日：2013-08-07

公开日：2013-12-18

语种：英文

收录：DERWENT

摘要：NOVELTY - A pyrrole derivative (I) is new. USE - Pyrrole derivative (I) used for preparing medicine i.e. tablet, pastille, capsule, dispersant, suspension, solution, and/or membrane for treating androgen receptor activity-related disorder, particularly prostate cancer, prostatic hyperplasia, hirsutism, acne, baldness, breast cancer, and/or sexual excitement (claimed). DETAILED DESCRIPTION - A pyrrole derivative of formula (I) is new. Q=optionally substituted 1-6C alkyl, 2-6C alkenyl, optionally substituted phenyl, O, 5 or 6-membered heterocyclic group, and/or 8-12 heteroaromatic bicyclic ring, where the substituent is halo, CN, -NO2, ester, trifluoromethyl, trifluoroacetyl, trifluoromethanesulfonyl, R1, OR1, NR1R2, C(O)R1, C(O)OR1, C(O)NR1R2, SR1, S(O)mR1, S(O)2NR1R2, OC(O)R1, OC(O)NR1R2, OS(O)2R1, OS(O)2NR1R2, N(R2)C(O)R1, N(R2)C(O)NR1R2, N(R2)S(O) or N(R2)S(O)2NR1R2; R1, R2=H, 1-6C alkyl, 1-6C alkoxy, 1-6C haloalkyl, 2-6C alkenyl, halogenated 2-6C alkenyl, 2-6C alkynyl, halo, optionally substituted 37C cycloalkyl, 57C cycloalkenyl, phenyl, 5-6C heterocyclic, or 8-12C heteroaromatic bicyclic ring, where substituent is halo, CN, -NO2, ester, trifluoromethyl, 1-6C alkyl, 1-6C haloalkyl, 2-6C alkenyl, 2-6C haloalkenyl, 2-6C alkynyl, hydroxy, OR3, NR3R4, C(O)R3, C(O)OR3, C(O)NR3R4, SR3, S(O)mRY3, S(O)2NR3R4, OC(O)R3, OC(O)NR3R4, OS(O)2R3, OS(O)2NR3R4, N(R3)C(O)R4, N(R3)C(O)NR4R5, N(R3)S(O)2R4 or N(R3)S(O)2NR4R5; R3-R5=H, 1-6C alkyl, 1-6C haloalkyl, 2-6C alkenyl, 2-6C haloalkenyl, 2-6C alkynyl, or 2-6C haloalkynyl; A=H, optionally substituted 1-9C alkyl, 1-6C alkyl and aryl, 2-6C alkenyl, 2-6C alkynyl, 3-7C cycloalkyl, 5-7C cycloalkenyl, 3-7C heterocyclic-alkyl, 5 or 6-membered heterocyclic ring, 6-12C aryl, where the substituent is halo; X=-NH, O, or S; and n=1-3. m=0-2. An INDEPENDENT CLAIM is included for preparation of compound (I).