文献类型：期刊文献

英文题名："Xanthene" is a premium bridging group for xanthenoid dyes

作者：Li, Jin[1];Zhang, Mengmeng[1];Yang, Lu[3];Han, Yubing[3];Luo, Xiao[2];Qian, Xuhong[1];Yang, Youjun[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, State Key Lab Bioreactor Engn, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China;[2]East China Normal Univ, Sch Chem & Mol Engn, Shanghai 200062, Peoples R China;[3]Coll Opt Sci & Engn, State Key Lab Modern Opt Instrumentat, Hangzhou 310027, Peoples R China

年份：2021

卷号：32

期号：12

起止页码：3865

外文期刊名：CHINESE CHEMICAL LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000771784000029)】；

基金：The work is financially supported by the National Natural Science Foundation of China (Nos. 21822805, 21908065, 22078098 the Science and Technology Commission of Shanghai Municipality for the Shanghai International Cooperation Program (No. 18430711000), the China Postdoctoral Science Foundation (Nos. 2019M651427, 2020T130197).

语种：英文

外文关键词：NIR infrared; Xanthene; Carbon rhodamine; Steric protect; Rigidity

摘要：Novel xanthenoid dyes by replacing the central oxygen atom of the xanthene dyes with less electron-rich bridging groups have been intensively sought after primarily for their long spectral wavelengths. However, the new scaffolds are likely prone to nucleophilic attack at their central methane carbon, as the result of the reduced electron density of the fluorochromic scaffolds. We envisage that the bridging group may be harnessed to sterically shield the central methane carbon from incoming nucleophiles and render high stability and synthesized xantheno-xanthene dyes. Additionally, the xantheno-bridging group can be modified via electrophilic aromatic substitution to introduce functionalities, e.g., sulfonate groups. (C) 2021 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.