文献类型：期刊文献

英文题名：Rare Earth Elements Lanthanum and Praseodymium Adversely Affect Neural and Cardiovascular Development in Zebrafish (Danio rerio)

作者：Zhao, Yanbin[1,2];Liang, Jiahui[1];Meng, Haoyu[1];Yin, Yue[3];Zhen, Huajun[2,3];Zheng, Xuehan[1];Shi, Haochun[1];Wu, Xiuzhi[4];Zu, Yao[4];Wang, Bin[5,6];Fan, Liuyin[7];Zhang, Kun[1,2]

机构：[1]Shanghai Jiao Tong Univ, Sch Environm Sci & Engn, Shanghai 200240, Peoples R China;[2]Shanghai Inst Pollut Control & Ecol Secur, Shanghai 200092, Peoples R China;[3]East China Univ Sci & Technol, Sch Resources & Environm Engn, State Environm Protect Key Lab Environm Risk Asse, Shanghai 200237, Peoples R China;[4]Shanghai Ocean Univ, Coll Fisheries & Life Sci, Shanghai 200090, Peoples R China;[5]Peking Univ, Inst Reprod & Child Hlth, Beijing 100191, Peoples R China;[6]Natl Hlth Commiss Peoples Republ China, Key Lab Reprod Hlth, Beijing 100191, Peoples R China;[7]Shanghai Jiao Tong Univ, Student Innovat Ctr, Shanghai 200240, Peoples R China

年份：2021

卷号：55

期号：2

起止页码：1155

外文期刊名：ENVIRONMENTAL SCIENCE & TECHNOLOGY

收录：;EI(收录号：20210209762865);WOS:【SCI-EXPANDED(收录号:WOS:000612354700036)】；

基金：We thank D. Z. and L. J. (Shanghai Jiao Tong University, Shanghai) for supporting on zebrafish embryo experiments. We thank K. F. [University of Applied Sciences and Arts Northwestern Switzerland and Swiss Federal Institute of Technology (ETH Zurich)] and Y. X. (Shanghai Jiao Tong University, Shanghai) for critically reading the manuscript and making valuable suggestions. Financial support from the Shanghai Pujiang Program [19PJ1404900] and the National Natural Science Foundation of China [21976121 and 22006099] is gratefully acknowledged.

语种：英文

外文关键词：Heart - Rare earths - Risk assessment - Praseodymium - Praseodymium compounds - Aquatic organisms - Electric resistance

摘要：Increasing rare earth element (REE) mining and refining activities have led to a considerable release of these substances into aquatic environment, yet the knowledge of their impacts on aquatic organisms is still limited. Here, we explored the developmental effects of 16 REEs (concentration ranged from 0.46 to 1000 mg/L) to zebrafish embryos and highlighted the adverse effects of lanthanum (La) and praseodymium (Pr). Among the multiple developmental parameters measured, the significant effects on swimming behavior and cardiac physiology were the most prominent. Transcriptomic analysis of La and Pr at concentrations of 1.1 to 10 mg/L revealed their rather uniform effects at molecular levels. The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways analysis revealed that among others, notch, glutamate, and serotonin signaling, as well as cardiac hypertrophy and cardiac muscle contraction, were significantly affected. These changes of neural signaling were consistent with behavior effects observed and supported by neurotransmitter changes and thus provide a reasonable molecular mechanistic explanation. Furthermore, increased DNA damage and apoptotic activity at high concentrations were observed, especially in the heart. They may contribute to explain the observed adverse morphological and physiological outcomes, such as pericardial edema. The effect concentrations observed in the present study were comparable to the concentrations of REE residues at highly contaminated sites (several mg/L), indicating ecotoxicological effects at environmentally relevant concentrations. Overall, the present data help to clarify the potential developmental toxicity of REEs that was not yet fully recognized and thus contribute to their environmental risk assessment.