文献类型：期刊文献

英文题名：Hybrid nanocomposite multinetwork hydrogel containing magnesium hydroxide nanoparticles with enhanced antibacterial activity for wound dressing applications

作者：Qu, Jiahao[1];Li, Jing[1];Zhu, Weiping[1];Xu, Yufang[1];Zhou, Shengmin[2];Yang, Yangyang[1];Qian, Xuhong[1,3]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Biotechnol, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

年份：2022

卷号：251

外文期刊名：POLYMER

收录：;EI(收录号：20222012111952);WOS:【SCI-EXPANDED(收录号:WOS:000798120500002)】；

基金：This work was supported by National Natural Science Foundation of China (Grant No. 31600802) and Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：Mg(OH)(2) nanoparticles; Nanocomposite hydrogel; Antibacterial

摘要：Efficient and cost-effective antibacterial materials are urgently needed owing to the antibiotic abuse and the threat of drug-resistant bacteria. Here we develop a hybrid nanocomposite hydrogel composed of Mg(OH)2 nanoparticles (MgNPs), chitosan (CS), sodium alginate and polyacrylamide, called MgNPs/CS hydrogel. MgNPs/ CS hydrogel presents excellent mechanical properties, high biocompatibility and improved broad-spectrum antibacterial activity. Particularly, the integration of MgNPs improves the stiffness and tensile strength of hydrogel without decreasing toughness. Moreover, MgNPs/CS hydrogel significantly enhances in vivo wound healing process in a skin defect rat model and the healing efficiency is much higher than sterile gauze and multisentry. Importantly, all the materials used in MgNPs/CS hydrogel are low-cost and accessible, indicating that MgNPs/CS hydrogel is more cost-effective and more feasible in practice. These results demonstrate that MgNPs/CS hydrogel can serve as an antibacterial dressing and contribute to the development of next-generation antibacterial materials.