文献类型：期刊文献

英文题名：Organocatalytic enantioselective Strecker reaction of cyclic trifluoromethyl-ketoimines

作者：Xie, Hexin[1,2];Song, Aiguo[1];Song, Xixi[1];Zhang, Xinshuai[1];Wang, Wei[1,2]

机构：[1]Univ New Mexico, Dept Chem & Chem Biol, Albuquerque, NM 87131 USA;[2]E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China

年份：2013

卷号：54

期号：11

起止页码：1409

外文期刊名：TETRAHEDRON LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000315306900018)】；

基金：Financial support of this research is provided by the National Science foundation (CHE-1057569), the China 111 Project (Grant B07023) and East China University of Science & Technology. We also acknowledge the NSF for providing support of NMR facilities at UNM (NSF grants 0840523 and 0946690).

语种：英文

外文关键词：Amine thiourea; Ketoimines; Organocatalysis; Strecker reaction

摘要：A quinine thiourea promoted enantioselective Strecker reaction of cyclic ketoimines with TMSCN has been developed. The process affords new enantioenriched trifluoromethyl dihydroquinazolinones in high yields and with high enantioselectivities. (C) 2013 Elsevier Ltd. All rights reserved.