文献类型：期刊文献

英文题名：Iron oxide/manganese oxide co-loaded hybrid nanogels as pH-responsive magnetic resonance contrast agents

作者：Wang, Xia[1,2];Niu, Dechao[3];Wu, Qing[1,2];Bao, Song[1,2];Su, Teng[1,2];Liu, Xiaohang[4];Zhang, Shengjian[4];Wang, Qigang[1,2]

机构：[1]Tongji Univ, Dept Chem, Shanghai 200092, Peoples R China;[2]Tongji Univ, Adv Res Inst, Shanghai 200092, Peoples R China;[3]E China Univ Sci & Technol, Sch Mat Sci & Engn, Lab Low Dimens Mat Chem, Key Lab Ultrafine Mat,Minist Educ, Shanghai 200237, Peoples R China;[4]Fudan Univ, Dept Radiol, Shanghai Canc Hosp, Shanghai 200032, Peoples R China

年份：2015

卷号：53

起止页码：349

外文期刊名：BIOMATERIALS

收录：;EI(收录号：20151700773378);WOS:【SCI-EXPANDED(收录号:WOS:000353929800033)】；

基金：This work was financially supported by the National Natural Science Foundation of China (21274111, 51402215), the Program for New Century Excellent Talents in University of Ministry of Education of China (NECT-11-0386), the Recruitment Program of Global Experts and China Postdoctoral Science Foundation (2014M550245).

语种：英文

外文关键词：Nanogel; Magnetic resonance imaging; Acid-responsive; Superparamagnetic iron oxide particles; Manganese species

摘要：This work described a proof of concept study of hybrid nanogel-based magnetic resonance contrast agents, SPIO@GCS/acryl/biotin@Mn-gel, abb. as SGM, for highly efficient, pH-responsive T-1 and T-2 dual-mode magnetic resonance imaging (Mm). SGM have been synthesized by assembling superparamagnetic iron oxide particles into polysaccharide nanoclusters, followed by in-situ reduction of the manganese species on the clusters and a final mild polymerization. The dual-mode SGM showed an interesting pH-responsiveness in in vitro MRI, with both T-1 and T-2 relaxivities turned "ON" in the acidic environment, along with an increase in the r(1) and r(2) relaxivity values by 1.7-fold (from 8.9 to 153 mM(-1) S-1) and 4.9-fold (from 45.7 to 226 mM(-1) S-1), due to desirable silencing and de-silencing effects. This interesting acidic-responsiveness was further verified in vivo with both significantly brightened signal of tumor tissue in T-1-weighted MR images and a darkened signal in T-2-weighted MR images 50 min post-injection of SGM. This smart hybrid nanogel may serve as a promising candidate for further studies of dual-mode (T-1 and T-2) contrast agents in MRI, due to its high stability, interesting pH-response mechanism and indicative imaging of tumors. (C) 2015 Elsevier Ltd. All rights reserved.