文献类型：期刊文献

英文题名：Copper-Catalyzed Benign and Efficient Oxidation of Tetrahydroisoquinolines and Dihydroisoquinolines Using Air as a Clean Oxidant

作者：Zheng, Bo[1,2];Trieu, Tien Ha[2];Li, Feng-Lei[2];Zhu, Xing-Liang[2];He, Yun-Gang[2];Fan, Qi-Qi[2];Shi, Xiao-Xin[1,2]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, 130 Mei Long Rd, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Pharm, Dept Pharmaceut Engn, 130 Mei Long Rd, Shanghai 200237, Peoples R China

年份：2018

卷号：3

期号：7

起止页码：8243

外文期刊名：ACS OMEGA

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000440615900033)】；

基金：We are grateful to the National Natural Science Foundation of China (nos. 20972048, 20172015) for the financial support of this work.

语种：英文

摘要：A green chemical method for mild oxidation of 1,2,3,4-tetrahydroisoquinolines (THIQs) and 3,4-dihydroisoquinolines (DHIQs) has been developed using air (O-2) as a clean oxidant. DHIQs and THIQs could be efficiently oxidized to isoquinolines in dimethyl sulfoxide at 25 degrees C under an open air atmosphere with CuBr2 (20 mol %) as the catalyst; different bases [NaOEt and/or 1,8-diazabicyclo[5,4,0] undec-7-ene] were used for the reaction according to the patterns of substituents (R-1, R-2).