文献类型：期刊文献

英文题名：Targeted delivery of photoactive diazido PtIV complexes conjugated with fluorescent carbon dots

作者：Yang, Xiao-Dong[1,2];Xiang, Hui-Jing[1,2];An, Lu[3,4];Yang, Shi-Ping[3,4];Liu, Jin-Gang[1,2]

机构：[1]E China Univ Sci & Technol, Key Lab Adv Mat MOE, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Dept Chem, Shanghai 200237, Peoples R China;[3]Shanghai Normal Univ, Key Lab Resource Chem MOE, Shanghai 200234, Peoples R China;[4]Shanghai Normal Univ, Shanghai Key Lab Rare Earth Funct Mat, Shanghai 200234, Peoples R China

年份：2015

卷号：39

期号：2

起止页码：800

外文期刊名：NEW JOURNAL OF CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000349222800002)】；

基金：This study was financially supported by the NSF of China (21271072), the Program for Professor of Special Appointment (Eastern Scholar) at the Shanghai Institutions of Higher Learning, and sponsored by the Shanghai Pujiang Program (13PJ1401900).

语种：英文

摘要：A novel Pt-IV-azide@carbon dots (CDs) nanoplatform for photo-controlled targeted platinum drug delivery was developed. The Pt-IV-N-3-FA@CDs nanoplatform selectively targeted folate-receptor overexpressed cancer cells while being simultaneously traced based on its inherent fluorescence; and it showed no dark cytotoxicity even in the presence of reducing glutathione, whereas it was readily photo-activated by either UV or visible light, producing cytotoxicity at a level comparable with that of cisplatin.