文献类型：期刊文献

英文题名：Inhibiting Radiative Transition-Mediated Multifunctional Polymeric Nanoplatforms for Highly Efficient Tumor Phototherapeutics

作者：Zhu, Yucheng[1];Chen, Chao[1];Yang, Guoliang[1];Wu, Qinghua[2,3];Tian, Jia[1];Hao, Erhong[2,3];Cao, Hongliang[1];Gao, Yun[1];Zhang, Weian[1]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn Ctr, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China;[2]Anhui Normal Univ, Minist Educ, Lab Funct Mol Solids, Anhui Lab Mol Based Mat,State Key Lab Cultivat Ba, Wuhu 241000, Anhui, Peoples R China;[3]Anhui Normal Univ, Sch Chem & Mat Sci, Wuhu 241000, Anhui, Peoples R China

年份：2020

卷号：12

期号：40

起止页码：44523

外文期刊名：ACS APPLIED MATERIALS & INTERFACES

收录：;EI(收录号：20204509452396);WOS:【SCI-EXPANDED(收录号:WOS:000579956100012)】；

基金：This work was financially supported by the National Natural Science Foundation of China (21875063), the Science and Technology Commission of Shanghai Municipality for the Shanghai International Cooperation Program (19440710600), and the Open Funding Project of the State Key Laboratory of Bioreactor Engineering. All animal procedures were performed in accordance with Chinese legislation on the Use and Care of Research Animals (Document no. 55, 2001), and institutional guidelines for the Care and Use of laboratory animals established by the East China University of Science and Technology Animal Studies Committee, and this committee approved the experiments.

语种：英文

外文关键词：inhibiting radiative transition; BODIPY; H2O2-responsive; GSH-depletion; tumor phototherapy

摘要：It is highly desired to explore ideal phototherapeutic narioplatforms, especially containing satisfactory phototherapeutic agents (PTAs), for potential cancer therapies. Herein, we proposed an effective strategy for designing a highly efficient PTA through inhibiting radiative transition (IRT). Specifically, we developed an ultralow radiative BODIPY derivative (TPA-IBDP) by simply conjugating two triphenylamine units to iodine-substituted BODIPY, which could simultaneously facilitate the nonradiative decay channels of singlet-to-triplet intersystem crossing and intramolecular charge transfer. In comparison to the normal BODIPY compound, TPA-IBDP exhibited an outstanding singlet oxygen yield (31.8-fold) and a higher photothermal conversion efficiency (PCE; over 3-fold), respectively, benefiting from the extended pi-conjugated donor-to-accepter (D-A) structure and the heavy atom effect. For tumor phototherapy using TPA-IBDP, TPA-IBDP was conjugated with a H2O2-responsive amphiphilic copolymer POEGMA(10)-b-[PBMA(5)-co-(PS-N-3)(2)] to construct a multifunctional photo therapeutic BODIPY-based nanoplatform (PB). PB produced abundant singlet oxygen (O-1(2)) and heat along with negligible fluorescence emission under near-infrared laser irradiation. Additionally, PB could generate a GSH-depletion scavenger (quinone methide, QM) after reacting with the abundant intracellular H2O2 in tumor for the cooperative enhancement of IRT-mediated phototherapy. We envision that this highly efficient multifunctional phototherapeutic nanoplatform cooperated by GSH-depletion could be a valuable paradigm for tumor treatments.