文献类型：期刊文献

英文题名：Self-Nanoemulsifying Drug Delivery System (SNEDDS) of Anethole Trithione by Combined Use of Surfactants

作者：Ren, Fuzheng[1];Jing, Qiufang[1];Cui, Jingbin[1];Chen, Jianming[2];Shen, Yongjia[3]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Dept Pharmaceut Engn, Shanghai 200237, Peoples R China;[2]Second Mil Med Univ, Sch Pharm, Shanghai, Peoples R China;[3]E China Univ Sci & Technol, Inst Fine Chem, Adv Mat Lab, Shanghai 200237, Peoples R China

年份：2009

卷号：30

期号：5

起止页码：664

外文期刊名：JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY

收录：;EI(收录号：20092912202145);WOS:【SCI-EXPANDED(收录号:WOS:000265334400015)】；

基金：The authors would like to thank the supports of research fund for the excellent young teachers by SMEC and ECUST.

语种：英文

外文关键词：Anethole trithione; dissolution; self-nanoemulsifying drug delivery system; surfactant

摘要：The characteristics of self-nanoemulsifying drug delivery system (SNEDDS) of Anethole trithione (ATT) for oral administration by the combined use of surfactants were investigated. In combination with surfactants, the SNEDDS provided smaller particle size, more oil loading, and shorter emulsification time. ATT from the SNEDDS rapidly dissolved in dissolution media whereas the ATT tablets showed different dissolution patterns according to the dissolution media. Furthermore, loading of ATT in SNEDDS improved the stability of ATT, and particle size of ATT nanoemulsion generated upon dilution was kept constant both in simulated gastric fluid and simulated intestinal fluid without enzyme.