文献类型：期刊文献

英文题名：Cuproptosis nanoprodrug-initiated self-promoted cascade reactions for postoperative tumor therapy

作者：Yan, Ruiqi[1];Cheng, Xuan[1];Song, Yujing[1];Wang, Haiyue[1];Zhang, Run[1];Jin, Yiqi[1];Li, Xingguang[2];Chen, Yu[1];Xiang, Huijing[1]

机构：[1]Shanghai Univ, Sch Life Sci, Shanghai 200444, Peoples R China;[2]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai Key Lab Funct Mat Chem, Key Lab Adv Mat, Shanghai 200237, Peoples R China

年份：2025

卷号：318

外文期刊名：BIOMATERIALS

收录：;EI(收录号：20250817893011);WOS:【SCI-EXPANDED(收录号:WOS:001447260400001)】；

基金：This work greatly acknowledge the final support of the National Natural Science Foundation of China (Grant No. T2322018, 32171391, and 22201073) , Shanghai Rising-Star Program (Grant No. 22QA1403600) , and the Fundamental Research Funds for the Central Universities. The schematic illustration is created with BioRender.com .

语种：英文

外文关键词：Tumor therapy; Cuproptosis; Nanoprodrug; Oxidative stress amplification; In-situ chemotherapy

摘要：Cancer metastasis and recurrence remain a regular cause of postoperative death in patients, implying that extra consolidation treatment strategies are needed. Here, a cuproptosis nanoprodrug, termed as Lipo@CP@DQ NPs, is developed to initiate self-promoted cascade reactions to achieve the combinational effect of cuproptosis, in situ chemotherapy, and oxidative stress amplification for effectively suppressing tumor recurrence and metastasis after postoperative treatment. Lipo@CP@DQ NPs are fabricated by loading copper peroxides (Cu2O2, CP) and hydrogen peroxide (H2O2)-repsonsive prodrug DQ into liposomal nanoparticles. Lipo@CP@DQ NPs rapidly dissociate in the acidic tumor microenvironment to release copper ions, H2O2, and prodrug DQ. Subsequently, the excessive accumulation of Cu ions induces cuproptosis and produces highly cytotoxic hydroxyl radicals (center dot OH). Meanwhile, the self-supplied H2O2 catalyzes the decomposition of DQ to diethyldithiocarbamate (DTC), which is chelated with self-supplied Cu ions to form the anticancer compound, Cu(DTC)2. The another decomposition product, quinone methide (QM), acts as a glutathione (GSH) scavenger for oxidative stress amplification. The synergistic effect of Lipo@CP@DQ NPs-mediated cuproptosis, in situ chemotherapy, and oxidative stress amplification effectively inhibits the growth and postoperative recurrence of triple-negative breast cancer. This work furnishes a strategy for developing cuproptosis-based nanomedicines for effective antitumor treatment after surgery.