文献类型：专利

英文题名：L-carnitine hydrogel patch for treating male infertility comprises medicine-containing matrix layer that comprises hydrogel matrix/L-carnitine/penetration enhancer/tackifier, coated onto back lining layer and covered with protective layer

作者：CAI H;GUO W;LIU Y;NIE Y;WANG J;WU K;TIAN X

机构：[1]UNIV EAST CHINA SCI&TECHNOLOGY

申请号：CN102697755-A

申请日：2012-06-15

公开日：2012-10-03

语种：英文

收录：DERWENT

摘要：NOVELTY - A L-carnitine hydrogel patch comprises a medicine-containing matrix layer, back lining layer and a protective layer. The substrate comprises a hydrogel matrix, L-carnitine, penetration enhancer and a tackifier. The mass ratio of L-carnitine and hydrogel matrix is 1:20 to 300. The hydrogel matrix comprises (%): penetration enhancers (1-2), tackifiers (1-5). USE - For the treatment of male infertility. ADVANTAGE - The L-carnitine hydrogel patch increases the long term disease medicine compliance. Administration of the L-carnitine hydrogel patch avoids liver first-pass effect and gastrointestinal tract degradation of medicine so that the effect of the medicine without being influenced by the gastrointestinal tract; and also controls the drug close to constant speed, which avoids the other preparation of several medicine caused by blood medicine peak valley fluctuation. DETAILED DESCRIPTION - A L-carnitine hydrogel patch comprises a medicine-containing matrix layer, backing layer and a protective layer. The substrate comprises a hydrogel matrix, L-carnitine, penetration enhancer (1-2) and a tackifier (1-5). The mass ratio of L-carnitine and hydrogel matrix is 1:20 to 300. The hydrogel matrix comprises (%): base material (5-20), humectant (15-30), cross linking agent (0.05-1); crosslinking agent modifier (0.05-1); filler (1-5) and distilled water (50-70). The penetration enhancer is selected from vitamin, phospholipids, fatty acid and its ester, polyol, amine, cyclodextrin, amino acid and its ester (preferably water soluble vitamin E or menthol). The tackifier is selected from konjac gum, sodium alginate, gelatin, pectin or chitosan (preferably sodium alginate gum or hyaluronic acid). The backing layer is made of at least one of artificial cotton cloth, non-woven cloth, compound aluminum foil or flange velvet. The protective layer is made of at least one of polypropylene film, polyethylene film, glass paper, polyester, paper or fluorine-containing material. The cross-linking agent is selected from at least one of citric acid, malic acid, lactic acid, tartaric acid, ethylene diamine tetraacetic acid and/or butene diacid, polyacrylic acid, sodium polyacrylate, potassium polyacrylate, carbomer, sodium carboxymethyl cellulose, methyl cellulose, polyvinyl pyrrolidone and Polyacrylamide. The crosslinking agent comprises a modifier is selected from at least one of the following: aluminum chloride, dihydroxyaluminum aminoacetate, aluminum starch, alum, aluminum hydroxide, calcium sulfate, calcium chloride or calcium hydroxide. The humectant is selected from at least one of glycerol, propylene glycol, sorbitol, butylene glycol and/or polyethylene glycol. The filler is selected from at least one of kaolin, starch, superfine silica gel powder or ceramic powder. An INDEPENDENT CLAIM is included for a method for preparing the L-carnitine hydrogel patch involving (A) adding base material of hydrogel matrix, filler, cross-linker, cross-linking modifier to carbomer humectant, stirring at room temperature for 5-35 minutes to obtain the uniform dispersed phase; (B) adding tackifier, L-carnitine and penetration agent into distilled water according to the above proportion, at 60-95 degrees C under the condition of constant speed stirring for 20-45 minutes to obtain the completely dissolved solution; (C) at constant speed stirring the obtained in step A to uniformly disperse in the step B solution, at a constant speed stirring for 10-35 minutes to mix uniformly to obtain the medicine-containing substrate at 75 degrees C for 5 to 20 minutes; (D) coating medicine containing matrix uniformly on the back lining layer, covering with protection layer, sterilizing according to the standard preparation, screening, carrying out quality inspection and packing.