文献类型：期刊文献

英文题名：A Green and Novel Method for the Synthesis of 4,4-Difluoro-3-oxo-2-(triphenylphosphoranylidene) δ-Lactones by Reformatsky Reaction

作者：Ibrayim, Saidalimu[1,2];Fang Xiang[1,2];Zhang Dong[1,2];Liu Wu[1,2];Wu Fanhong[1,2,3]

机构：[1]E China Univ Sci & Technol, Sch Chem & Mol Engn, Adv Mat Lab, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Sch Chem & Mol Engn, Inst Fine Chem, Shanghai 200237, Peoples R China;[3]Shanghai Inst Technol, Sch Chem & Environm Engn, Shanghai 200235, Peoples R China

年份：2011

卷号：29

期号：12

起止页码：2713

外文期刊名：CHINESE JOURNAL OF CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000298016700025)，CCR-EXPANDED(收录号:WOS:000298016700025)】；

基金：Project supported by the National Natural Science Foundation of China (NNSFC) (Nos. 20972050, 21172148).

语种：英文

外文关键词：aqueous medium; 4-bromo-4,4-difluoro-3-oxo-2-(triphenylphosphoranylidene)butanoate; Reformatsky reaction; indium

摘要：In the presence of In/CuCl, ethyl 4-bromo-4,4-difluoro-3-oxo-2-(triphenylphosphoranylidene)butanoate reacted with various aldehydes in aqueous medium at room temperature to give the alpha,alpha-difluorinated beta-hydroxy carbonyl compounds. Furthermore, treating Reformatsky addition compounds with 1 equiv. of sodium hydroxide in the mixture of tetrahydrofuran and water afforded gem-difluoromethylenated 2-triphenylphosphoranylidene delta-lactones in excellent yields.