文献类型：期刊文献

中文题名：多组分反应在合成含肽类药物开发中的应用

英文题名：Application of Multicomponent Reactions in the Synthesis of Peptide Drugs

作者：赵传猛[1];曹松[1];刘年金[1];申丽[1];李利娜[1];钱旭红[1]

机构：[1]华东理工大学药学院药物化工研究所上海市化学生物学(芳香杂环)重点实验室,上海200237

年份：2006

卷号：69

期号：10

起止页码：762

中文期刊名：化学通报

外文期刊名：Chemistry

收录：CSTPCD;;Scopus;北大核心:【北大核心2004】；CSCD:【CSCD2011_2012】；

基金：国家重点基础研究发展计划(973计划)(2003CB114400)资助项目

语种：中文

中文关键词：多组分反应;合成;肽;药物

外文关键词：Multicomponent reaction, Synthesis, Petide, Drug, Pepticide

摘要：多组分反应可以快速大量的合成结构复杂的药物分子,因此现代药物开发与多组分反应的发展密切相关。本文总结了近年来国内外有关多组分反应研究的发展概况及其在含肽链类新药物开发中的应用研究进展。
Modern drug discovery depends heavily on the use of muhicomponent reaction （MCR） for the rapid assembly of complex drug-like molecules. MCR have been used to create diversity oriented and biased combinatorial libraries, to accopmlish the synthesis of highly complex natural products as well as for the large-scale production of drug candidates. Today, the discovery of novel MCR has become an increasingly active area of research, yielding novel chemical scaffolds for drug discovery efforts. This paper focuses mainly on the recent development of muhicomponent reactions and their applications to the discovery of new peptide drugs.