文献类型：期刊文献

英文题名：A Concise Colorimetric and Fluorimetric Probe for Sarin Related Threats Designed via the "Covalent-Assembly" Approach

作者：Lei, Zuhai[2];Yang, Youjun[1,2]

机构：[1]E China Univ Sci & Technol, Sch Pharm, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China

年份：2014

卷号：136

期号：18

起止页码：6594

外文期刊名：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

收录：;EI(收录号：20142017731560);WOS:【SCI-EXPANDED(收录号:WOS:000335720200017)】；

基金：The work is supported by Sponsored by Shanghai Rising-Star Program (No. 13QA1401200), Innovation Program of Shanghai Municipal Education Commission (No. 12ZZ047), Doctoral Fund of Ministry of Education of China (No. 20110074120008) and the National Natural Science Foundation of China (Nos. 21106043 and 21372080). We thank Prof. Amanda E. Hargrove and Dr. Michelle A. Ivy for help with manuscript preparation.

语种：英文

外文关键词：Colorimetry

摘要：A turn-on signal from zero background allows sensitive detection of a weak signal and is highly desired. The "covalent-assembly" probe design principle is powerful in this regard. Herein, we report an embodiment of this principle (NA570) for detection of Sarin related threats, based on a phenylogous Vilsmeier-Haack reaction. NA570 bears a concise molecular construct, exhibits a colorimetric and a fluorimetric signal, and has potential for real applications.