文献类型：期刊文献

英文题名：Influences of mesoporous zinc-calcium silicate on water absorption, degradability, antibacterial efficacy, hemostatic performances and cell viability to microporous starch based hemostat

作者：Hou, Yu[1];Xia, Yan[2];Pan, Yongkang[1];Tang, Songchao[1];Sun, Xiaofei[3];Xie, Yang[3];Guo, Han[4];Wei, Jie[1]

机构：[1]East China Univ Sci & Technol, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China;[2]Second Mil Med Univ, Changhai Hosp, Dept Emergency, Shanghai 200433, Peoples R China;[3]Second Mil Med Univ, Changhai Hosp, Dept Orthoped, Shanghai 200433, Peoples R China;[4]Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai Synchrotron Radiat Facil, Shanghai 201800, Peoples R China

年份：2017

卷号：76

起止页码：340

外文期刊名：MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS

收录：;EI(收录号：20171203468685);WOS:【SCI-EXPANDED(收录号:WOS:000405541600041)】；

基金：This work was supported by the National Key Research and Development Program [2016YFC1102100], the National Natural Science Foundation of China [81271705, 31271031], the Major International Joint Research Project between China and Korea [81461148033], and the National Research Foundation of Korea (NRF) Grant [NRF-2014K2A2A7066637], and China Scholarship Council (CSC)-German Academic Exchange Service (DAAD) PPP project [No. 2014-6065] and CSC [No. 201206740003].

语种：英文

外文关键词：Mesoporous zinc-calcium silicate; Microporous starch; m-ZCS/MS composites; Antibacterial property; Hemostatic performance

摘要：Efficacious hemostatic agents have significant potential application in visceral organ or large vessel arterial injure. In this study, mesoporous zinc-calcium silicate (m-ZCS) was synthesized, and microporous starch (MS) based hemostatic agents of m-ZCS/MS composites for hemorrhage control was fabricated. The results showed that the incorporation of m-ZCS into MS significantly enhanced the water absorption and degradability of the composites, which were dependent on the m-ZCS content Moreover, the composites with antibacterial property could inhibit the growth of Escherichia coli (E. coli) and the antibacterial ratios increased with the m-ZCS content. The in vitro coagulation evaluation by using activated partial thromboplastin time (APTT) and prothrombin time (PT) revealed that the composites significantly activated the intrinsic and extrinsic pathway of coagulation cascade. In addition, for the animal model of rabbits in ear vein, skin, arterial and liver injuries, the hemostatic time of the composites obviously reduced with the increase of m-ZSC content, in which the composite with 15 wt% m-ZCS content (15mZSC) showed remarkable efficacy on bleeding control. The composites could promote the viability of L929 cells,.indicating no cytotoxicity of the composites. The results suggested that the m-ZCS/MS composites with excellent hemostatic and antibacterial properties might be a candidate for controlling bleeding and infection. 2017 Published by Elsevier B.V.