文献类型：期刊文献

中文题名：双氯芬酸钠微乳凝胶的研制与体外透皮性能的初步考察

英文题名：Preparation and Preliminary Investigation of in vitro Transdermal Property of Diclofenac Sodium Microemulsion-based Hydrogel

作者：刘玲玲[1];胡强[1];沈淑慧[1];余伟民[1];崔景斌[1]

机构：[1]华东理工大学药学院药剂学教研室,上海200237

年份：2013

卷号：44

期号：11

起止页码：1111

中文期刊名：中国医药工业杂志

外文期刊名：Chinese Journal of Pharmaceuticals

收录：CSTPCD;;北大核心:【北大核心2011】；CSCD:【CSCD2013_2014】；

语种：中文

中文关键词：双氯芬酸钠;微乳凝胶;制备;透皮

外文关键词：diclofenac sodium; microemulsion-based hydrogel; preparation; transdermal

摘要：比较了卡波姆980、羟丙甲纤维素(1×104mPa·s)和Sangelose 90L作为双氯芬酸钠微乳水凝胶基质的效果。结果仅以卡波姆980为骨架材料时可得到金黄色透明的微乳凝胶。该制品黏度为(6 000±2.65)mPa·s,pH值为6.5±0.5,稳定性较好。继续以小鼠离体皮肤为模型考察其体外透皮特性,并与市售凝胶对比。结果表明,自制微乳凝胶12 h累积透过量高于市售凝胶,稳态渗透速率为(20.08±0.73)g·cm-2·h-1,明显高于市售凝胶[(9.47±0.41)g·cm-2·h-1]。
The effects of three kinds of matrix, carbopol 980, HPMC （1×104 mPa·s） and Sangelose 90L, for diclofenac sodium microemulsion-based hydrogel were compared. The results showed that the transparent yellow microemulsion-based hydrogel was only available with carbopol 980 as a substrate. The viscosity and pH value of the product were （6 000±2.65） mPa.s and 6.5±0.5, respectively. The product was also rather stable. The in vitro transdermal property through excised mouse skin was investigated. Compared with the commercial hydrogel, the cumulative amount at 12 h of the microemulsion-based hydrogel was higher. The steady-state penetration rate of microemulsion-based hydrogel was （20.08±0.73） μg·cm-2·h-1, which was higher than that of commercial hydrogel [ （9.47±0.41） μg·cm-2·h-1].