文献类型：期刊文献

英文题名：Self-Assembled Aza-Boron-Dipyrromethene for Ferroptosis-Boosted Sonodynamic Therapy

作者：You, Changwen[1];Li, Xingguang[3,4];Wang, Dongqiong[1];Chen, Hongzhong[2];Liang, Lei[1];Chen, Yu[1];Zhao, Yanli[2];Xiang, Huijing[1,2]

机构：[1]Shanghai Univ, Sch Life Sci, Materdicine Lab, Shanghai 200444, Peoples R China;[2]Nanyang Technol Univ, Sch Chem Chem Engn & Biotechnol, 21 Nanyang Link, Singapore 637371, Singapore;[3]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Sch Chem & Mol Engn, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[4]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Sch Chem & Mol Engn, Feringa Nobel Prize Scientist Joint Res Ctr, Shanghai 200237, Peoples R China

年份：2022

卷号：61

期号：41

外文期刊名：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

收录：;EI(收录号：20223612696830);WOS:【SCI-EXPANDED(收录号:WOS:000849629700001)】；

基金：We greatly acknowledge the financial support from the National Natural Science Foundation of China (32171391 and 51902336), the Shanghai Science and Technology Program (21010500100), the Basic Research Program of Shanghai Municipal Government (21JC1406002), the Shanghai Rising-Star Program (22QA1403600), the Singapore National Research Foundation Investigatorship (NRF-NRFI2018-03), and the Singapore Agency for Science, Technology and Research (A*STAR) AME IRG grant (A20E5c0081).

语种：英文

外文关键词：Cysteine Starvation; Ferroptosis; Organic Nanomedicine; Sonodynamic Therapy; Tumor Therapy

摘要：The presence of apoptosis inhibition proteins renders the cancer cells resistant to apoptosis, severely compromising the antitumor efficacy of sonodynamic therapy (SDT). Here, an intelligent anticancer nanoplatform based on an Aza-boron-dipyrromethene dye (denoted as Aza-BDY) is elaborately established for ferroptosis augmented SDT through cysteine (Cys) starvation. After endocytosis by tumor cells, Aza-BDY serves as both a ferroptosis inducing agent and a sonosensitizer for tumor treatment. The specific Cys response facilitates the disruption of redox homeostasis and initiation of cellular ferroptosis. Meanwhile, the released sonosensitizer causes efficient SDT and augments ferroptosis under ultrasound irradiation. Detailed in vitro and in vivo investigations demonstrate that the synergistic effect of Cys depletion and singlet oxygen (O-1(2)) generation significantly induces cancer-cell death and suppresses tumor proliferation with a high inhibition rate of 97.5 %.