文献类型：期刊文献

英文题名：Heparin-immobilized polymers as non-inflammatory and non-thrombogenic coating materials for arsenic trioxide eluting stents

作者：Gong, Feirong[3];Cheng, Xiaoyan[3];Wang, Shanfeng[1];Zhao, Yanchao[3];Gao, Yun[3];Cai, Haibo[2]

机构：[1]Univ Tennessee, Dept Mat Sci & Engn, Knoxville, TN 37996 USA;[2]E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[3]E China Univ Sci & Technol, Sch Mat Sci & Engn, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China

年份：2010

卷号：6

期号：2

起止页码：534

外文期刊名：ACTA BIOMATERIALIA

收录：;EI(收录号：20215111347390);WOS:【SCI-EXPANDED(收录号:WOS:000274277800025)】；

基金：This work was supported by the 863 Project of 2007AA02Z450 from the Ministry of Science and Technology of China. We thank Jianguo Jia, Wei Yang and Ruiming Yao, of the Shanghai Institute of Cardiovascular Diseases, for their help with the animal implantations. We also thank Shanghai Aosi Biological Technology Service Co., Ltd. for help with the histological analysis. The detailed and helpful comments from the reviewers are gratefully appreciated.

语种：英文

外文关键词：Stent; Biodegradability; Heparin; Arsenic trioxide (As2O3); Restenosis

摘要：We have synthesized heparin-immobilized copolymers Of L-lactide (LA) and 5-methyl-5-benzyloxycarbonate-1,3-dioxan-2-one (MBC) as non-inflammatory and non-thrombogenic biodegradable coating materials. These copolymers were used in fabricating arsenic trioxide (As2O3)-eluting stents to reduce the late-stage adverse events, such as thrombosis, localized hypersensitivity and inflammation, that occur when applying stents to treat coronary artery diseases. Heparinized copolymers effectively reduced platelet adhesion and protein adsorption while increasing the plasma recalcification time and thromboplastin time in vitro. Histological analysis of the polymer-coated stents in a porcine coronary artery injury model indicated that one heparinized copolymer (Hep-Co90, LA:MBC = 90:10), with the highest LA content of 90% and the lowest degradation rate, induced the least foreign body reactions and inflammation, which were as small as those induced by bare metal stents. Consequently, Hep-Co90 was used as the stent coating material for local As2O3 delivery. Histomorphometric evaluations suggested no significant difference between bare metal stents and As2O3-eluting stents at I and 3 months post-implantation. At 6 months, the lumen area in the porcine coronary arteries treated with As2O3-eluting stents is 32.4% higher than those treated with bare metal stents while the neointimal area, neointimal thickness and stenosis rate decreased by 25.8%, 32.5% and 31.2%, respectively. The As2O3-eluting stent using Hep-Co90 as the drug carrier and stent coating material presented in this study represents a novel promising device in preventing in-stent restenosis. (C) 2009 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.