文献类型：期刊文献

中文题名：聚合物异相成核对加巴喷丁晶型的控制和选择

英文题名：The crystalline polymorph control and selection of gabapentin with polymer heteronuclei

作者：杨柳[1];茹敏良[1];郎美东[1]

机构：[1]华东理工大学材料科学与工程学院,上海市先进聚合物材料重点实验室,超细材料制备与应用教育部重点实验室,上海200237

年份：2010

卷号：45

期号：1

起止页码：109

中文期刊名：药学学报

外文期刊名：Acta Pharmaceutica Sinica

收录：MEDLINE(收录号：21351459);CSTPCD;;Scopus;北大核心:【北大核心2008】；CSCD:【CSCD2011_2012】；PubMed;

基金：上海市重点学科和重点实验室项目资助(B502、08DZ2230500)

语种：中文

中文关键词：加巴喷丁;多晶型;异相成核;晶型的选择和控制

外文关键词：gabapentin polymorph polymer heteronuclei crystalline polymorph control and selection

摘要：药物晶型对药物的物理、化学和生物利用度等诸多性能具有重要的影响。本文通过聚合物异相成核研究了加巴喷丁晶型的培养方法,以X-射线粉末衍射、红外光谱、DSC分析等方法对培养的加巴喷丁晶型进行了分析和表征。结果表明,聚合物异相成核是一种对加巴喷丁进行晶型选择和控制的有效方法,本文不但培养了加巴喷丁所有已知的晶型,而且还发现了一种新的加巴喷丁晶型。
The pharmaceutical properties, including the physical and chemical properties, and the bioavailability are greatly influenced by their polymorphism. In this paper the polymer heteronuclei were used to produce the gabapentin polymorphs that were characterized by X-ray powder diffraction, FT-IR and DSC. The results indicated that the polymer heteronuclei are an effective method to control and select the gabapentin polymorphism. One new polymorph of gabapentin was found besides all known gabapentin polymorphs.