文献类型：期刊文献

英文题名：In vivo ratiometric tracking of endogenous β-galactosidase activity using an activatable near-infrared fluorescent probe

作者：Shi, Limin[1];Yan, Chenxu[1];Ma, Yiyu[1];Wang, Ting[1];Guo, Zhiqian[1];Zhu, Wei-Hong[1]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai Key Lab Funct Mat Chem, Inst Fine Chem,Sch Chem & Mol Engn, Shanghai 200237, Peoples R China

年份：2019

卷号：55

期号：82

起止页码：12308

外文期刊名：CHEMICAL COMMUNICATIONS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000491549100003)】；

基金：This work was supported by the NSFC/China (21622602, 21788102, 21421004, 21636002, 21878087 and 21908060), the National Key Research and Development Program (2017YFC-0906902), the Innovation Program of Shanghai Municipal Education Commission, the Scientific Committee of Shanghai (15XD1501400), the Shuguang Program (18SG27) and the China Postdoctoral Science Foundation (Grant 2019M651417). This study was performed in strict accordance with the NIH guidelines for the care and use of laboratory animals and was approved by the Institutional Animal Care and Use Committee of the National Tissue Engineering Center (Shanghai, China).

语种：英文

摘要：Herein, we developed a dual-channel and light-up near-infrared fluorescent probe for ratiometric sensing of beta-galactosidase (beta-gal) activity. The well-designed probe, which shows ratiometric optical response with a significant red-shift (from 575 nm to 730 nm), was successfully applied to detect endogenous beta-gal activity in SKOV-3 cells and tumor-bearing mice.