文献类型：期刊文献

英文题名：Antimicrobial evaluation and action mechanism of pyridinium-decorated l,4-pentadien-3-one derivatives

作者：Zhou, Jian[1];Tao, Qing-Qing[1];Wang, Pei-Yi[1];Shao, Wu-Bin[1];Wu, Zhi-Bing[1];Li, Zhong[2];Yang, Song[1,2]

机构：[1]Guizhou Univ, State Key Lab Breeding Base Green Pesticide & Agr, Key Lab Green Pesticide & Agr Bioengn, Minist Educ,Ctr R&D Fine Chem, Guiyang 550025, Guizhou, Peoples R China;[2]East China Univ Sci & Technol, Coll Pharm, Shanghai 550025, Peoples R China

年份：2018

卷号：28

期号：10

起止页码：1742

外文期刊名：BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000432729000012)】；

基金：We acknowledge the financial support of the Key Technologies R&D Program (2014BAD23B01), National Natural Science Foundation of China (21372052, 21662009), the Research Project of Ministry of Education of China (20135201110005, 213033A), and Guizhou Provincial S&T Program ([2012]6012, [2016]1029).

语种：英文

外文关键词：Pyridinium; 1,4-Pentadien-3-one; Synthesis; Action mechanism; Antimicrobial

摘要：A type of pyridinium-decorated l,4-pentadien-3-one derivatives possessing flexible alkyls were designed and synthesized by integrating the key scaffolds of pyridinium cations and l,4-pentadien-3-one skeleton in a single molecular architecture. Antimicrobial bioassays indicated that some of the target molecules exerted considerable bioactivities against six phytopathogenic strains, especially for Xanthomonas oryzae pv. oryzae, the minimal EC50 value can reach to 0.504 mu g/mL. A plausible action mechanism for this land of compounds was proposed and confirmed by employing fluorescent spectroscopy, fluorescence microscopy, and scanning electron microscopy. We anticipated that this finding can promote high-efficient lead compounds discovery in the research of antimicrobial chemotherapy. (C) 2018 Elsevier Ltd. All rights reserved.