文献类型：期刊文献

英文题名：Photocalibrated NO Release from N-Nitrosated Napthalimides upon One-Photon or Two-Photon Irradiation

作者：Zhang, Ziqian[2];Wu, Jiayao[2];Shang, Zhihao[2];Wang, Chao[4];Cheng, Jiagao[2,3];Qian, Xuhong[1,2];Xiao, Yi[4];Xu, Zhiping[2];Yang, Youjun[1,2]

机构：[1]East China Univ Sci & Technol, Sch Pharm, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China;[4]Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116024, Liaoning, Peoples R China

年份：2016

卷号：88

期号：14

起止页码：7274

外文期刊名：ANALYTICAL CHEMISTRY

收录：;EI(收录号：20163002640972);WOS:【SCI-EXPANDED(收录号:WOS:000380296800044)】；

基金：The work is supported by the Fundamental Research Funds for the Central Universities (Nos. WY1514053 and WY1516017) and the National Natural Science Foundation of China (NOs. 21236002, 21372080 and 21572061).

语种：英文

外文关键词：Photons

摘要：NO donors are routinely used as the exogenous source in in vitro studies. However, the kinetics or the dose of NO release from the existing donors is not readily monitored. This complicates the elucidation of the involvement of NO in a biological response. We report herein a series of NO donors (NOD545a-g), whose NO release is triggered by UV light at 365 nm or a two-photon laser at 740 nm, and importantly, their NO release is accompanied by a drastic fluorescence turn-on, which has been harnessed to follow the kinetics and dose of NO release in a real-time fashion with spectroscopic methods or microscopic methods in in vitro studies. These merits have rendered NOD545a-g useful molecular tools in NO biology.