文献类型：期刊文献

英文题名：Recent advances in polysaccharide-dominated extracellular polymeric substances from microalgae: A review

作者：He, Yulong[1];Ji, Liang[1];Yuan, Yuchen[1];Rui, Die[1];Li, Jiaxin[1];Cheng, Pengfei[4];Sun, Liyun[1,2];Fan, Jianhua[1,2,3]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Dept Appl Biol, Shanghai 200237, Peoples R China;[3]Shihezi Univ, Sch Chem & Chem Engn, State Key Lab Incubat Base Green Proc Chem Engn, Shihezi 832003, Peoples R China;[4]Ningbo Univ, Coll Food Sci & Engn, Ningbo 315211, Zhejiang, Peoples R China

年份：2025

卷号：302

外文期刊名：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

收录：;EI(收录号：20250617818433);WOS:【SCI-EXPANDED(收录号:WOS:001424161400001)】；

基金：This work was sponsored by National Key Research and Development Project of China 2020YFA0907304, "Innovation Yongjiang 2035" Key R & D Programme-International Sci-tech Cooperation Projects 2024H002, Natural Science Foundation of Shandong Province ZR2019ZD17, Natural Science Foundation of Shanghai 23ZR1415100 and 24ZR1490800, Funding Project of the State Key Laboratory of Bioreactor Engineering and Shanghai Collaborative Innovation Center for Biomanufacturing Technology.

语种：英文

外文关键词：Extracellular polymeric substances; Polysaccharides; Monosaccharide; Secretion; Bioactivity; Microalgae

摘要：Microalgae are an environmentally friendly and sustainable alternative resource for future food and pharmaceutical production. Microalgal extracellular polymeric substances (EPMS) are polymers consisting of polysaccharides, proteins, lipids and nucleic acids secreted by microalgal cells. This review systematically summarizes the research progress of microalgal EPMS, including its composition, structure, formation, biological activity and application. The diversity of structural units and binding modes confers microalgal EPMS with unique structural and biological activity, which is species-specific. In addition to the polysaccharides with antioxidant, antiviral, and antitumor effects, extracellular vesicles isolated from microalgal EPMS are emerging as new drug carriers. However, challenges such as relatively low yields, complex separation techniques, intricate processing-secretion pathways, and unclear mechanisms of action still hinder the industrial application of microalgal EPMS. By scientifically summarizing the research progress and leveraging strategies such as metabolic regulation, genetic modification, and advanced separation and characterization technologies, microalgal EPMS is expected to see widespread applications in the food, cosmetics, and therapeutic industries.