文献类型：期刊文献

英文题名：Preparation and osteogenic properties of magnesium calcium phosphate biocement scaffolds for bone regeneration

作者：Li, X.[1];Niu, Y.[2];Guo, H.[3];Chen, H.[1];Li, F.[4];Zhang, J.[1];Chen, W.[4];Wu, Z.[1];Deng, Y.[1];Wei, J.[1];Liu, C.[1]

机构：[1]E China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China;[2]Second Mil Med Univ, Dept Orthopaed, Changhai Hosp, Shanghai 200433, Peoples R China;[3]Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai Synchrotron Radiat Facil, Shanghai 201800, Peoples R China;[4]Shanghai 8th Peoples Hosp, Dept Pharmaceut, Shanghai 200235, Peoples R China

年份：2013

卷号：8

外文期刊名：JOURNAL OF INSTRUMENTATION

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000322572900010)】；

基金：This study was supported by grants from the National Natural Science Foundation of China (No. 31100680, No. 81000799), the National Natural Science Foundation of China (No. 81172989, No. 81271705) and Nano special program of Science and Technology Development of Shanghai (No. 12nm0500400).

语种：英文

外文关键词：Computerized Tomography (CT) and Computed Radiography (CR); Medical-image reconstruction methods and algorithms, computer-aided so; X-ray radiography and digital radiography (DR)

摘要：The regenerative treatment of large osseous defects remains a formidable challenge in today. In the present study, we have synthesized biodegradable magnesium calcium phosphate biocement (MCPB) scaffolds with interconnected macroporous structure (100-600 mu m), as well as good bioactivity, biocompatibility and proper degradatibility. The results revealed that the porosity increased from 52% to 80% of MCPB scaffolds while the compressive strength decreased from 6.1MPa to 1.2MPa. We further assessed the effects of scaffolds on the rabbit femur cavity defect model in vivo by using synchrotron radiation X-ray microCT and microCT imaging, indicating that the MCPB scaffolds underwent gradually degradation and promoted the extensive neo-bone formation.