文献类型：期刊文献

英文题名：Bis-coenzyme Q0: Synthesis, characteristics, and application

作者：Wang, Xiuwen[1]; Ma, Wei[1]; Ying, Yilun[1]; Liang, Jie[1]; Long, Yi-Tao[1]

机构：[1] Key Laboratory for Advanced Materials, Department of Chemistry, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, China

年份：2011

卷号：6

期号：4

起止页码：1064

外文期刊名：Chemistry - An Asian Journal

收录：EI(收录号：20111313877281)

语种：英文

外文关键词：Reduction - Electron transitions - Electron transport properties - Electron spin resonance spectroscopy - Coenzymes - Hydrogen bonds - Spectroelectrochemistry

摘要：A methylene-bridged bis-coenzyme Q0, bis(2,3-dimethoxy-5-methyl- l,4-benzoquinone)methane (Bis-CoQ0), that shows intramolecular electronic communications has been synthesized for the first time. By employing electrochemical, in situ UV/Vis, and electron paramagnetic resonance (EPR) spectroelectrochemical techniques, the unstable reduced intermediate speciesa-monoradicals, diamagnetic dianions and tetraanions of Bis-CoQ 0a-have been observed. The electron-transfer process can be defined as a three-step reduction process with a total of four electrons in solution in CH3CN. The chemical reaction in the third redox step process was confirmed by variable temperature cyclic voltammetry. In an aprotic CH 3CN solution, the peak potential separation between electron-transfer steps diminished sequentially with increasing concentration of water. The hydrogen-bonding interactions between water and the electrochemically reduced intermediates of Bis-CoQ0 can be estimated by peak potential shifts. The electronic communications of Bis-CoQ0 may have been blocked when one reduction peak was observed with proper quantities of water in CH 3CN solution. The antioxidant defense capacity of Bis-CoQ 0-protected cells has also been assessed. ? 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.