文献类型：期刊文献

英文题名：Cellular membrane-targeting ruthenium complexes as efficient photosensitizers for broad-spectrum antibacterial activity

作者：Wang, Yi[1];Hu, Ya-Tao[2];Zhang, Hai-Lin[1];Chen, Yu-Yu[2];Shi, Hong-Dong[3];Liu, Jin-Gang[1];Zhang, Qian-Ling[2]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]Shenzhen Univ, Coll Chem & Environm Engn, Shenzhen Key Lab Funct Polymer, Shenzhen 518060, Peoples R China;[3]Kunming Med Univ, Sci & Technol Achievement Incubat Ctr, Yunnan Key Lab Stem Cell & Regenerat Med, Kunming 650500, Peoples R China

年份：2023

卷号：52

期号：23

起止页码：8051

外文期刊名：DALTON TRANSACTIONS

收录：;EI(收录号：20232414246122);WOS:【SCI-EXPANDED(收录号:WOS:000995269400001)】；

基金：This study was financially supported by the National Natural Science Foundation of China (no. 22177078 and 21571062), the Program for Professor of Special Appointment (Eastern Scholar) at the Shanghai Institutions of Higher Learning to JGL, and the Fundamental Research Funds for the Central Universities (no. 222201717003). We are also grateful to the Instrumental Analysis Center of Shenzhen University (Xili Campus) for providing the facilities for our studies.

语种：英文

外文关键词：Cytology - Escherichia coli - Medical applications - Photodynamic therapy - Ruthenium compounds

摘要：A ruthenium complex [Ru( phen)(2)( phen-5-amine)-C14] (Ru-C14) with broad-spectrum antibacterial activity was designed and synthesized; positively charged Ru-C14 could target bacteria via electrostatic interactions and showed high binding effectiveness to cell membranes. In addition, Ru-C14 could act as a photosensitizer. Under 465 nm light irradiation, Ru-C14 could generate O-1(2), thus disrupting the bacterial intracellular redox balance and leading to bacterial death. Ru-C14 also exhibited minimum inhibitory concentration values of 6.25 mu M against Escherichia coli and 3.125 mu M against Staphylococcus aureus; these values are lower than those of streptomycin and methicillin. This work combined the merits of cell membrane targeting and photodynamic therapy for antibacterial activity. The findings might open up a new avenue for effective anti-infection treatment and other medical applications.