文献类型：期刊文献

英文题名：Enhanced photodynamic therapy based on an amphiphilic branched copolymer with pendant vinyl groups for simultaneous GSH depletion and Ce6 release

作者：Cao, Hongliang[1];Zhong, Sheng[1];Wang, Qiusheng[1];Chen, Chao[2];Tian, Jia[1];Zhang, Weian[1]

机构：[1]East China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai Key Lab Funct Mat Chem, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Biotechnol, Biomed Nanotechnol Ctr, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

年份：2020

卷号：8

期号：3

起止页码：478

外文期刊名：JOURNAL OF MATERIALS CHEMISTRY B

收录：;EI(收录号：20200608120003);WOS:【SCI-EXPANDED(收录号:WOS:000508846000010)】；

基金：This work was supported by the Shanghai Natural Science Foundation (18ZR1408300) and the National Natural Science Foundation of China (No. 21574039 and 21875063).

语种：英文

外文关键词：Photosensitizers - Nanosystems - Controlled drug delivery - Targeted drug delivery - Nanoparticles

摘要：Photodynamic therapy would suffer from low efficiency in the cancer treatment process if the reactive oxygen species (ROS) generated from a photosensitizer (PS) were reduced by intracellular glutathione (GSH). To overcome this limitation, in this work, we developed an amphiphilic branched copolymer with pendant vinyl groups, and it self-assembled with chlorin e6 (Ce6) into nanoparticles to fabricate a GSH-reaction response drug delivery system. The vinyl groups in the hydrophobic core of the nanoparticles were reacted with GSH by a "thio-ene" click reaction to release Ce6; simultaneously, the level of GSH decreased for enhanced PDT. Both in vitro and in vivo studies demonstrated that remarkable PDT efficacy for the nanosystem can be achieved.