文献类型：期刊文献

英文题名：Effects of carbon sources on fungal morphology and lovastatin biosynthesis by submerged cultivation of Aspergillus terreus

作者：Jia, Zhihua[1]; Zhang, Xiaoli[2]; Cao, Xuejun[1]

机构：[1] State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 200237, Shanghai, China; [2] College of Chemical Engineering, Northwest University, 710069, Xia'n, China

年份：2009

卷号：4

期号：5

起止页码：672

外文期刊名：Asia-Pacific Journal of Chemical Engineering

收录：EI(收录号：20100212624243)

语种：英文

外文关键词：Aspergillus - Starch - Sugars - Morphology - Carbon

摘要：The influences of various carbon sources on fungal morphological changes and lovastatin production were investigated in submerged cultivation of a mutant of Aspergillus terreus. Lactose produced the least biomass (2.3 ± 0.15 gDCW l-1); however, the highest maximal specific lovastatin productivity (ρmax) was obtained. Glycerol achieved the highest lovastatin titer (937.5 ± 12.5 mg l-1), while soluble starch resulted in the highest biomass (12.05 ± 0.05 gDCW l-1) and the second highest lovastatin titer (501.3 ± 23.4 mg l-1). With the carbon source turning to be more easily metabolized, the values of ρmax dropped gradually while the corresponding Dp and mean filament ratio rose tardily. The value of Pmax (19.8 mg gDCW-1 d-1) was obtained in the presence of lactose while glucose resulted in the least ρmax (3.0 mg gDCW-1 d-1). This led to a 6.6-fold decrease. The corresponding D p and mean filament ratios appeared to reverse the effects, thus producing 1.9 and 3.3-fold increases, respectively. The slowly utilizable carbon sources regulated the lovastatin production through both the inducement of fungal morphology differentiation and the control of metabolic regulation. ? 2009 Curtin University of Technology and John Wiley & Sons, Ltd.