文献类型：期刊文献

英文题名：Studies towards DIAD promoted N-demethylation of N,N-dimethylanilines

作者：Ren, Jiangmeng[1];Cao, Fu-Rong[1];Sun, Xue-Qin[1];Xu, Xuan[1];Liu, Gui-Xia[1];Zeng, Bu-Bing[1]

机构：[1]East China Univ Sci & Technol, Shanghai Frontiers Sci Ctr Optogenet Tech Cell Met, Sch Pharm, 130 Meilong Rd, Shanghai, Peoples R China

年份：2022

卷号：103

外文期刊名：TETRAHEDRON LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000839332700015)，CCR-EXPANDED(收录号:WOS:000839332700015)】；

语种：英文

外文关键词：Diisopropyl azodicarboxylate (DIAD); Metabolites; Demethylation; N-dimethylanilines; N

摘要：The demethylation of N,N-dimethylanilines promoted by diisopropyl azodicarboxylate (DIAD) to provide N-methylanilines was achieved in this paper. This protocol featured with mild reaction condition, simple operation and moderate to good yield. The intermediates were isolated and identified by means of spec-troscopy methods. The reaction mechanism was investigated experimentally and further verified by the-oretical calculations. This method could be applied to the study of the metabolites of medicines containing N,N-dimethylaniline fragments.(c) 2022 Published by Elsevier Ltd.