文献类型：期刊文献

中文题名：α-磺酰胺芳基酰胺化合物的合成研究

英文题名：Facile Synthesis and Research of α-Sulfonamides Aryl Amides

作者：李飞龙[1];胡雅雯[2];王玉麟[1];赵敏[1];陈建中[2]

机构：[1]华东理工大学化学与分子工程学院,上海200237;[2]上海交通大学化学化工学院,上海200240

年份：2018

卷号：40

期号：9

起止页码：823

中文期刊名：化学试剂

外文期刊名：Chemical Reagents

收录：CSTPCD;;北大核心:【北大核心2017】；

语种：中文

中文关键词：α-氨基酰胺;α-磺酰胺芳基酰胺;合成;生物活性物质

外文关键词：α-aminoamide;α-sulfamide aryl amides;synthesis;bioactive compounds

摘要：以最常见的芳基乙酮为原料,经二氧化硒氧化得到相应芳基酮酸,在氯化亚砜氯化后直接与不同的胺反应得到一系列芳基酮酰胺,接着与磺酰胺加成得到关键中间体α-磺酰亚胺芳基酰胺,最后还原得到目标产物α-磺酰胺芳基酰胺。合成路线具有原料易得、操作方便、收率较高等优点,其结构经1HNMR、13CNMR、高分辨质谱、红外和熔点等手段表征。该产物可用于生物活性物质的合成中。
The aryl ketonic acid were prepared readily via oxidation reaction of substitutional acetophenones and subsequent chlorination and amination to afford the corresponding aryl keto-amides.The key intermediates α-sulfimide aryl amides were coupled with sulfamide.A series of α-sulfamide aryl amides were obtained with good yields after reduction.The structures were characterized by 1HNMR,13CNMR,HR-MS,IR and melting point measurement.The aminoamide products could subsequently be used in the synthesis of bioactive compounds.