文献类型：期刊文献

英文题名：Advanced nanomaterial-based analytical techniques for early detection of spinal diseases: From the perspective of sports medicine

作者：Fang, Wen[1];Wu, Yang[1];Yang, Zhenyu[1];Wang, Yu[2];Ye, Xinming[1]

机构：[1]East China Univ Sci & Technol, Sch Sports Sci & Engn, Shanghai 200237, Peoples R China;[2]Peking Univ First Hosp, Dept Orthopaed, Xishiku St 8, Beijing 100034, Peoples R China

年份：2026

卷号：204

外文期刊名：TRAC-TRENDS IN ANALYTICAL CHEMISTRY

收录：;EI(收录号：20263421335700);Scopus(收录号：2-s2.0-105047680078);WOS:【SCI-EXPANDED(收录号:WOS:001853470300001)】；

基金：This work was supported by the Project of School-enterprise Cooperation (No: L110-72301)

语种：英文

外文关键词：Nanotechnology; Spinal diseases; Sports medicine; Precision medicine; Drug delivery; Tissue engineering; Theranostics; Intervertebral disc degeneration; Spinal cord injury

摘要：Spinal diseases represent a significant health burden among athletes and physically active populations, with conditions ranging from intervertebral disc degeneration to traumatic spinal cord injuries substantially impacting athletic performance and quality of life. This comprehensive review synthesizes current evidence on the epidemiology of sports-related spinal diseases, elucidates the underlying pathological mechanisms. We discuss nano-imaging modalities including magnetic resonance imaging contrast enhancement, fluorescent nanoprobes, and molecular imaging techniques that enable early detection of degenerative changes. Therapeutic nanotechnology platforms encompassing liposomal formulations, polymeric nanoparticles, hydrogel systems, and nanofiber scaffolds are critically evaluated for their potential in drug delivery, tissue regeneration, and gene therapy. Furthermore, we explore the emerging paradigm of nanotheranostics that integrates diagnostic and therapeutic functions within single platforms, alongside intelligent stimuli-responsive nanosystems that enable precision-controlled interventions. The review concludes with perspectives on translating these innovations into clinical practice for athletes, emphasizing the need for individualized treatment strategies.