文献类型：期刊文献

英文题名：Integrated Bioinformatics Analysis Exhibits Pivotal Exercise-Induced Genes and Corresponding Pathways in Malignant Melanoma

作者：Zhu, Jun[1];Hao, Suyu[2];Zhang, Xinyue[3];Qiu, Jingyue[4];Xuan, Qin[5];Ye, Liping[6]

机构：[1]Shanghai Basil Clin, Adm Off, Shanghai, Peoples R China;[2]Shuangwu Informat Tech Co Ltd, Shanghai, Peoples R China;[3]Hangzhou Normal Univ, Sch Educ, Hangzhou, Peoples R China;[4]East China Univ Sci & Technol, Sch Phys Sci & Engn, Shanghai, Peoples R China;[5]East China Univ Sci & Technol, Sch Sports Sci & Engn, Shanghai, Peoples R China;[6]Fudan Univ, Minhang Hosp, Dept Clin Nursing, Shanghai, Peoples R China

年份：2021

卷号：11

外文期刊名：FRONTIERS IN GENETICS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000625199600001)】；

语种：英文

外文关键词：malignant melanoma; exercise; integrated bioinformatics analysis; Disease-free survival; prognosis

摘要：Malignant melanoma represents a sort of neoplasm deriving from melanocytes or cells developing from melanocytes. The balance of energy and energy-associated body composition and body mass index could be altered by exercise, thereby directly affecting the microenvironment of neoplasm. However, few studies have examined the mechanism of genes induced by exercise and the pathways involved in melanoma. This study used three separate datasets to perform comprehensive bioinformatics analysis and then screened the probable genes and pathways in the process of exercise-promoted melanoma. In total, 1,627 differentially expressed genes (DEGs) induced by exercise were recognized. All selected genes were largely enriched in NF-kappa B, Chemokine signaling pathways, and the immune response after gene set enrichment analysis. The protein-protein interaction network was applied to excavate DEGs and identified the most relevant and pivotal genes. The top 6 hub genes (Itgb2, Wdfy4, Itgam, Cybb, Mmp2, and Parp14) were identified, and importantly, 5 hub genes (Itgb2, Wdfy4, Itgam, Cybb, and Parp14) were related to weak disease-free survival and overall survival (OS). In conclusion, our findings demonstrate the prognostic value of exercise-induced genes and uncovered the pathways of these genes in melanoma, implying that these genes might act as prognostic biomarkers for melanoma.