文献类型：期刊文献

英文题名：Palladium-Catalyzed Tandem Carbene Migratory Insertion and Intramolecular Cyclization: Synthesis of Chromeno[4,3-b]chromene Compounds

作者：Shang, Xue Song[1];Li, Nian Tai[1];Siyang, Hai Xiao[1];Liu, Pei Nian[1]

机构：[1]E China Univ Sci & Technol, Key Lab Adv Mat & Inst Fine Chem, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China

年份：2015

卷号：80

期号：9

起止页码：4808

外文期刊名：JOURNAL OF ORGANIC CHEMISTRY

收录：;EI(收录号：20151900829672);WOS:【SCI-EXPANDED(收录号:WOS:000354004600065)，CCR-EXPANDED(收录号:WOS:000354004600065)】；

基金：This work was supported by the National Natural Science Foundation of China (project nos. 21172069, 21372072, and 21190033), the Science Fund for Creative Research Groups (21421004), NCET (NCET-13-0798), the Basic Research Program of the Shanghai Committee of Sci & Tech. (project no. 13M1400802), and the Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：Catalysis - Cyclization - Organic compounds - Scaffolds - Palladium compounds

摘要：Chromeno[4,3-b]chromene is a ubiquitous structural motif found in various pharmaceuticals and biologically active compounds. A concise palladium-catalyzed reaction of vinyl iodides and salicyl N-tosylhydrazones has been achieved to afford a series of compounds containing the chromeno[4,3-b]chromene scaffold in moderate to high yield. This tandem reaction involves palladium(II) carbene migratory insertion and intramolecular cyclization assisted by an O nucleophile and tolerates various functional groups.