文献类型：期刊文献

英文题名：One-Component Ionizable Amphiphilic Janus Dendrimers for Targeted mRNA Delivery

作者：Zhu, Pengyu[1];Li, Yongsheng[1,2];Zhang, Dapeng[1]

机构：[1]East China Univ Sci & Technol, Frontier Sci Ctr Mat Biol & Dynam Chem, Shanghai Engn Res Ctr Hierarch Nanomat, Key Lab Ultrafine Mat,Minist Educ,Sch Mat Sci & En, Shanghai 200237, Peoples R China;[2]Shihezi Univ, Sch Chem & Chem Engn, Key Lab Green Proc Chem Engn Xinjiang Bingtuan, Shihezi 832003, Peoples R China

年份：2025

卷号：64

期号：22

外文期刊名：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

收录：;EI(收录号：20251618242948);WOS:【SCI-EXPANDED(收录号:WOS:001466735300001)】；

基金：This work was financially supported by the National Key Research and Development Program of China (Grant Nos. 2022YFC2403200, 2024YFF0508600), the National Natural Science Foundation of China (No. 22305081), Basic Research Program of Shanghai (21JC1406003), Leading Talents in Shanghai in 2018, Shanghai Sailing Program (23YF1408600), the 111 project (B14018), the Key Field Research Program (No. 2023AB054), and the Fundamental Research Funds for the Central Universities of China. Drs. Drew Weissman and Virgil Percec are acknowledged for their constructive suggestions and guidance for the development of one-component IAJD based mRNA delivery platform.

语种：英文

外文关键词：Dendrimersome nanoparticles; Ionizable amphiphilic Janus dendrimers; mRNA delivery; One component; Organ-targeted delivery

摘要：mRNA nanomedicine represents a new generation of therapeutics. However, how to deliver mRNA to the desired organs and cells effectively remains challenging. Common mRNA delivery vectors include viral and nonviral types such as four-component lipid nanoparticles (LNPs), polymer-based nanoparticles, lipid-polymer hybrid nanoparticles, and so on. One-component ionizable amphiphilic Janus dendrimers (IAJDs), are an emerging type of mRNA delivery vehicle displaying good stability and high delivery efficiency. In this review, we comprehensively present the design, synthesis, and mRNA delivery properties of IAJDs, with particular focus on the relationship between their molecular structures and organ targeted delivery properties. Other representative types of dendrimers for RNA delivery are also reviewed. Overall, this review summarizes the recent research progress on IAJDs systematically, aiming to guide the development of more efficient mRNA delivery platforms and next-generation mRNA nanomedicines.